Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Building method of dry-eye animal model

A technology for establishing methods and animal models, applied in animal houses, applications, animal husbandry, etc., to achieve the effects of high repeatability, stable model, and single controllable inducing factors

Inactive Publication Date: 2017-06-20
XIAMEN UNIV
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of different animal models has certain limitations, and there is a certain gap with the actual clinical situation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Building method of dry-eye animal model
  • Building method of dry-eye animal model
  • Building method of dry-eye animal model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for establishing a dry eye animal model, the device used (such as figure 1 Shown) comprises a box-shaped body and a loam cake that is located on the box-shaped body, and appropriate amount of water is housed in the box-shaped body, and the depth of water is not more than the body length of rodent, and 1~5cm above the water surface is provided with for mice. Standing two support rods (fixed relative to the box-shaped body); the upper cover is provided with a solid food placement area and a water feeding area for the normal diet of mice; specifically comprises the following steps:

[0035] (1) Put the mouse on the support rod, cover the top cover, place solid food and drinking water, and change the water every 1 to 2 days to keep it clean;

[0036] (2) Make the mice stand in the device every day, and the standing time is the sleep deprivation time. After standing at 13:00-17:00 every afternoon, put the mice experimental animals into a common breeding cage to rest...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a building method of a dry-eye animal model. Devices in use comprise a box-shape body and an upper cover covering the box-shape body, the box-shape body is filled with an appropriate amount of liquid which does no chemical harm on mice, the depth of the liquid does not exceed the body lengths of the mice, and at least one supporting rod which allows the mice to stand on are arranged above the liquid level; the upper cover is provided with a solid food placing area and a water feeding area, so that the mice eat and drink normally. The method specifically comprises the first step of placing a mice laboratory animal on the supporting rod, covering the upper cover, placing solid food and water, and replacing the liquid at regular intervals; the second step of placing the mice laboratory animal in the device and making the mice laboratory animal stand every day, after the animal finished standing placing the mice laboratory animal into a common feeding cage for rest, and continuously repeating the second step so that the dry-eye animal model can be obtained, wherein the time for standing is the sleep deprived time. According to the building method of the dry-eye animal model, the production is simple, the repeatability is high, and the model is stable.

Description

technical field [0001] The invention belongs to the technical field of medical animal models, and in particular relates to a method for establishing a dry eye animal model. Background technique [0002] Dry eye refers to a class of diseases that cause tear film instability and / or abnormal ocular surface due to abnormal tear quality, quantity and dynamics, accompanied by ocular symptoms. Dry eye can be divided into: evaporative dry eye, water deficiency dry eye, mucin abnormal dry eye, abnormal tear dynamics dry eye and mixed dry eye. Clinical investigations show that dry eye is a common ocular surface disease, and can cause keratitis, corneal neovascularization, and corneal ulcers, which seriously affect people's quality of life and work efficiency. The common pathophysiological features of dry eye include damage to the ocular surface epithelial barrier, decreased tear fluid, decreased conjunctival goblet cells, and squamous metaplasia of the ocular surface epithelium. Due...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A01K1/03
CPCA01K1/031
Inventor 李炜李三明刘祖国宁可郭俞利周晶
Owner XIAMEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com