A kind of preparation method of hydroxytyrosol

A technology of hydroxytyrosol and ethanol, which is applied in the field of chemical synthesis of natural product hydroxytyrosol, can solve the problems of poor product quality, low yield, and unsuitability for industrial production, and achieve good color, high demethylation activity, and increased Effect of demethylation activity
CN106866384BActive Publication Date: 2020-11-06陕西嘉禾药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
陕西嘉禾药业有限公司
Publication Date
2020-11-06

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Abstract

The invention provides a preparation method of hydroxytyrosol. The preparation method comprises the following steps: uniformly stirring a solvent, 3,4-dimethoxyphenethyl alcohol and aluminum triiodide, adding boron trifluoride tetrahydrofuran or boron trifluoride diethyl etherate, carrying out heating and refluxing, cooling the mixture to room temperature after the reaction is completed, filtering, adding active carbon into filtrate, filtering again, recycling filtrate till all the filtrate is recycled, obtaining a light yellow oil residue, then adding methylene dichloride, carrying out refluxing, cooling to room temperature, pulping, and filtering the material, thus obtaining white powdered solid hydroxytyrosol. According to the preparation method, complicated operation of multiple extractions in a water phase in a conventional method is avoided; the content of a product is 98 percent or above, and the quality of the hydroxytyrosol is much higher than the product quality in the prior art.
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Description

technical field

[0001] The invention belongs to the field of organic chemistry and relates to a chemical synthesis method of natural product hydroxytyrosol. Background technique

[0002] Hydroxytyrosol, the chemical name is 2-(3,4-dihydroxyphenyl)ethanol. Hydroxytyrosol has a catechol structure and has strong oxidative properties. It has been applied to food and cosmetics in foreign countries for a long time. With continuous research, more medicinal values ​​of hydroxytyrosol have been discovered, such as anti-cancer , antibacterial, anti-inflammatory, and have significant effects on the prevention and treatment of arteriosclerosis, hypertension, heart disease, cerebral hemorrhage and other diseases. It is also widely used in the fields of health care products, food and cosmetics.

[0003]

[0004] In the prior art, the preparation of hydroxytyrosol mainly includes extraction and chemical synthesis from olive leaves, as follows:

[0005] Plant extraction is obtained fro...

Claims

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