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Application of a janus nanoparticle as an adhesive for filling materials in dental restorations

A nanoparticle and filling material technology, applied in dentistry, dental preparations, dental prostheses, etc., can solve the problems of insufficient bonding strength, strong hydrophilicity of HEMA, cytotoxicity, etc., and achieve a simple and easy preparation method and improve durability. performance, performance optimization

Active Publication Date: 2019-10-08
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem of insufficient bonding strength and cytotoxicity in the current HEMA by adding the Janus nanocomposite material synthesized by precise regulation into the oral and maxillofacial adhesive system. To provide an application of Janus nanoparticles as an adhesive for filling materials in dental restorations

Method used

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  • Application of a janus nanoparticle as an adhesive for filling materials in dental restorations
  • Application of a janus nanoparticle as an adhesive for filling materials in dental restorations
  • Application of a janus nanoparticle as an adhesive for filling materials in dental restorations

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Janus nanoparticles, the main body is silica, with amino groups on one side of the hemisphere and carbon-carbon double bonds on the other side; the size is about 100nm, and it is uniform spherical, such as figure 1 shown; white powder; non-toxic, such as figure 2 shown; it can stabilize the water / oil two phases in the adhesive without phase separation, such as image 3 shown.

[0031] Preparation of Janus nanoparticles, the specific steps are as follows:

[0032] 1) preparing biologically inert silica nanoparticles with a diameter of about 100 nm;

[0033] 2) Prepare surface amino-modified silica nanoparticles, use APTMS to modify, and modify at a temperature of 76°C;

[0034] 3) using the Pickering emulsion method to perform selective modification and selective chemical modification on the surface to prepare Janus nanoparticles;

[0035] The surface amino-modified silica nanoparticles obtained in step 2 are dispersed in the mixed system of water and paraffin; the ...

Embodiment 2

[0041] Janus nanoparticles, the main body is silicon dioxide, with amino groups on one side of the hemisphere, and carbon-carbon double bonds on the other side; white powder; non-toxic; the size is about 50nm, in a uniform spherical shape;

[0042] Preparation of Janus nanoparticles, the specific steps are as follows:

[0043] 1) preparing biologically inert silica nanoparticles with a diameter of about 50 nm;

[0044] 2) Prepare surface amino-modified silica nanoparticles, use APTMS to modify, and modify at a temperature of 76°C;

[0045] 3) Use the Pickering emulsion method to carry out selective modification and selective chemical modification on the surface to prepare Janus nanoparticles; disperse the amino-modified silica nanoparticles obtained in step 2 in a mixed system of water and paraffin; The mass ratio of modified silica nanoparticles, water, and paraffin is 1:600:10), and the reaction temperature is 70°C; stirring for 15 minutes makes the nano-biological particle...

Embodiment 3

[0051] Janus nanoparticles, the main body is silicon dioxide, with amino groups on one side of the hemisphere, and carbon-carbon double bonds on the other side; white powder; non-toxic; the size is about 10nm, in a uniform spherical shape;

[0052] Preparation of Janus nanoparticles, the specific steps are as follows:

[0053] 1) preparing biologically inert silica nanoparticles with a diameter of about 10 nm;

[0054] 2) Prepare surface amino-modified silica nanoparticles, use APTMS to modify, and modify at a temperature of 76°C;

[0055] 3) Use the Pickering emulsion method to carry out selective modification and selective chemical modification on the surface to prepare Janus nanoparticles; disperse the amino-modified silica nanoparticles obtained in step 2 in a mixed system of water and paraffin; The mass ratio of modified silica nanoparticles, water, and paraffin is 1:300:20; stir for 15 minutes to distribute nano-biological particles in a single layer of paraffin / water i...

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Abstract

The invention relates to application of Janus nanoparticles as an adhesive in dental repair filling materials, belonging to the field of dental repair. The area of different chemical composition regions, chemical composition, particle size distribution, double-bond group number and other important influencing factors of the Janus nano composite material are accurately controlled to prepare the nano-sized Janus material with polymerizable unsaturated double bonds at the hydrophobic side. The synthesized Janus nanoparticles are used instead of HEMA (hydroxyethyl methacrylate) (the hydrophilic component and hydrophobic component materials in the widely used stable adhesive at present) for bonding the filler resin-tooth interface to solve the problems of overhigh hydrophilicity, easy hydrolysis and destroy of the bonding interface and obvious cytotoxicity in the existing HEMA, constructing the long-acting stable adhesive layer, and enhancing the durability of the bonded material.

Description

technical field [0001] The invention relates to the application of Janus nanoparticles as an adhesive for dental restoration filling materials, belonging to the field of dental restoration. Background technique [0002] Since de Gennes of France gave his Nobel Prize Lecture in 1991, the word Janus was used for the first time to express the different chemical composition properties on both sides of the same particle, and it was predicted that Janus particles, similar to amphiphilic molecules, could self-assemble at the liquid / liquid interface. deGennes' enlightening talk sparked a wave of research on Janus particles. Janus micro- or nanoparticles with dual properties (hydrophilic / hydrophobic) on the surface endow micro- or nanoparticles with two different or even opposite (polar / non-polar, positive / negative charges, etc.) properties. At present, the types of Janus materials are becoming more and more abundant, and their special properties and attractive application prospects...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/06
CPCA61K6/871
Inventor 韩冰王晓燕夏文棣
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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