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A kind of ionic liquid gas chromatography stationary phase and application thereof for blood alcohol analysis

A technology of gas chromatography and ionic liquid, applied in the field of stationary phase of ionic liquid gas chromatography, can solve problems such as no related reports, achieve high chromatographic inertness, improve thermal stability, and high inertness

Active Publication Date: 2020-05-01
GANSU INST OF POLITICAL SCI & LAW
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although there are many research results on ionic liquid quartz capillary column stationary phase and chromatographic column at home and abroad, there are no relevant reports on the composition and structure of ionic liquid chromatography stationary phase and ionic liquid quartz capillary column for blood alcohol analysis.

Method used

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  • A kind of ionic liquid gas chromatography stationary phase and application thereof for blood alcohol analysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 An ionic liquid gas chromatographic stationary phase for blood alcohol analysis. The composition structure of the ionic liquid gas chromatographic stationary phase is as follows:

[0033] ;

[0034] The cation in the formula is an imidazole cation containing R group, R 1 For vinyl, R 2 , R 4 , R 5 Are all hydrogen atoms, R 3 Is propyl, [X] - Is bis-(trifluoromethanesulfonyl)imide [NTf 2 ] - .

[0035] The stationary phase of ionic liquid gas chromatography is a polar stationary phase, and its McReynolds constant at 120℃ ( ΔI ) Are: benzene (X') 346, butanol (Y') 733, 2-pentanone (Z') 760, 1-nitropropane (U') 927, pyridine (S') 1210.

Embodiment 2

[0036] Example 2 An ionic liquid gas chromatographic stationary phase for blood alcohol analysis. The composition structure of the ionic liquid gas chromatographic stationary phase is the same as that of Example 1.

[0037] The cation in the formula is an imidazole cation containing R group, R 1 For vinyl, R 2 , R 4 , R 5 Are all hydrogen atoms, R 3 Is propyl, [X] - Is trifluoromethanesulfonate [TFO] - .

[0038] The stationary phase of ionic liquid gas chromatography is a polar stationary phase, and its McReynolds constant at 120℃ ( ΔI ) Is: benzene (X') 136, butanol (Y') 523, 2-pentanone (Z') 366, 1-nitropropane (U') 324, pyridine (S') 608.

Embodiment 3

[0039] Example 3 An ionic liquid gas chromatographic stationary phase for blood alcohol analysis. The composition structure of the ionic liquid gas chromatographic stationary phase is the same as that of Example 1.

[0040] The cation in the formula is an imidazole cation containing R group, R 1 For vinyl, R 2 , R 4 , R 5 Are all hydrogen atoms, R 3 Is propyl, [X] - Is hexafluorophosphate [PF 6 ] - .

[0041] The stationary phase of ionic liquid gas chromatography is a polar stationary phase, and its McReynolds constant at 120℃ ( ΔI ) Are: benzene (X') 196, butanol (Y') 613, 2-pentanone (Z') 370, 1-nitropropane (U') 484, pyridine (S') 508.

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Abstract

The invention relates to an ionic liquid gas chromatography fixed phase for blood alcohol analysis, and application thereof. The composition structure formula of the ionic liquid gas chromatography fixed phase is as follows: (the formula is as shown in the description); in the formula, the cation is imidazolium cation containing R group, R1 is C2-C3 straight-chain terminal alkenyl, R2, R4 and R5 are methyl or hydrogen atom, and R3 is a C3-C9 straight chain or alkyl or aryl with a branched chain; and anion [X]<-> is trifluoromethyl sulfonate [TFO]<->, bi-(trifluoromethanesulfonyl)imide [NTf2]<-> or hexafluorophosphate [PF6]<->. The invention also discloses application of the fixed phase. The ionic liquid gas chromatography fixed phase can separate acetaldehyde, acetone, methanol, ethanol, isopropyl alcohol, normal propyl alcohol and butanol in blood alcohol analysis simultaneously and quickly.

Description

Technical field [0001] The invention relates to the field of gas chromatography analysis, in particular to an ionic liquid gas chromatography stationary phase for blood alcohol analysis and its application. Background technique [0002] Blood alcohol (Blood Alcohol) analysis plays an important role in forensic poisoning detection and is one of the important links in the detection of drunk driving and criminal cases involving alcohol. The simultaneous separation of acetaldehyde, acetone, methanol, ethanol, isopropanol, n-propanol and butanol in blood alcohol samples is the main technical problem in the analysis. The reason is that the current domestic chromatographic column manufacturing and research units cannot provide a Quartz capillary column for simultaneous analysis of the above components. Foreign commercial blood alcohol analysis chromatographic column brands include Restek’s Rtx-BAC plus1, Rtx-BAC plus2 chromatographic columns and Aglient’s DB-ALC1 and DB-ALC2 chromatogr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D15/12B01J20/292G01N30/02
CPCB01D15/12B01J20/292B01J2220/54B01J2220/58B01J2220/84B01J2220/86G01N30/02
Inventor 王仲来张露露
Owner GANSU INST OF POLITICAL SCI & LAW
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