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Use of methyl salicylate glycoside in the preparation of medicines for preventing and/or treating systemic lupus erythematosus and its complications

A technology of methyl salicylate glycoside and lupus erythematosus, which is applied in the field of preparation of drugs for the prevention and treatment of systemic lupus erythematosus and its complications, and can solve the problems of undisclosed applications of lupus erythematosus and its complications

Active Publication Date: 2021-04-13
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

No disclosure of its application in the preparation of products for the prevention and / or treatment of systemic lupus erythematosus and its complications

Method used

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  • Use of methyl salicylate glycoside in the preparation of medicines for preventing and/or treating systemic lupus erythematosus and its complications
  • Use of methyl salicylate glycoside in the preparation of medicines for preventing and/or treating systemic lupus erythematosus and its complications
  • Use of methyl salicylate glycoside in the preparation of medicines for preventing and/or treating systemic lupus erythematosus and its complications

Examples

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Effect test

experiment example 1

[0043]Experimental Example 1: The mouse model of systemic lupus erythematosus induced by pristane is a classic and widely recognized mouse model, which is often used to evaluate the pharmacological effects of anti-lupus drugs. The feeding, grouping and administration of mice were as follows: inbred BALB / c female mice (SPF grade, 7-8 weeks old) were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (certificate number: SCXK ( Beijing) 2012-0001; serial number: 11400700048526). BALB / c mice were kept in the barrier system of the Experimental Animal Center of Institute of Materia Medica, Chinese Academy of Medical Sciences from 1 week before modeling to the end of the experiment (6 months after modeling), with 5-7 mice / cage. The feeding conditions were: 25°C constant temperature, 50% relative humidity, regular feed and free drinking water, and 12h light / dark cycle.

[0044] In the first month after modeling, the modeling mice were screened according to...

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Abstract

The invention discloses the use of a class of methyl salicylate glycoside compounds represented by the general formula (1) and pharmaceutically acceptable salts thereof in the preparation of medicines for preventing and / or treating systemic lupus erythematosus and its complications. In the present invention, methyl salicylate glycoside has the pharmacological effect of reducing the expression levels of autoantibodies and inflammatory factors in lupus mice and improving immune function; it has the effect of slowing down the pathological process of lupus arthritis; The pharmacological effect of immune complex deposition and improving renal function in lupus mice; it has the effect of protecting spleen function in lupus mice. Methyl salicylate glycosides are monomeric compounds extracted and separated from the traditional Chinese herbal medicine Dianbaizhu, which has the advantages of low toxicity, simple extraction process, and mature synthetic route; its raw material resources are vast, and it is easy to prepare in large quantities. With good application and development prospects, it is an ideal new type of traditional Chinese medicine monomer for the treatment of complications such as systemic lupus erythematosus and its immune dysfunction, lupus arthritis, lupus nephritis, and lupus spleen injury.

Description

technical field [0001] The present invention relates to the new pharmacological effects of methyl salicylate glycosides and pharmaceutically acceptable salts thereof, and the use of methyl salicylate glycosides and pharmaceutically acceptable salts in the preparation of prevention and treatment of systemic lupus erythematosus Its application in medicines for complications and diseases; it belongs to the technical field of medicine. [0002] technical background [0003] Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease whose main pathological features are the production of autoantibodies and the deposition of immune complexes. health. Systemic lupus erythematosus is clinically manifested by systemic tissue damage, most notably the so-called facial rash (Butterfly). In addition to the skin, systemic lupus erythematosus usually affects almost all important tissues (such as joints) and organs (such as the heart, liver, brain, kidneys, and lungs). Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61P37/02A61P19/04A61P19/02A61P13/12A61P1/00A23L33/125
CPCA23V2002/00A61K31/7034A23V2200/30A23V2200/324A23V2250/60
Inventor 杜冠华方莲花张东明何阳阳阎雨林溢煌吴平张慧芳
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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