Alkaloid compound in purslane herb and extraction and separation method thereof

A separation method and alkaloid technology, applied in the direction of drug combination, organic chemistry, non-central analgesics, etc., can solve the problem of low structural consistency, and achieve the effect of environmentally friendly process method, simple and fast operation method

Active Publication Date: 2017-07-14
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0004] Most of the chemical components isolated from purslane are known at present, and the structure is relatively low. Therefore, the development and separation of new compounds in purslane is urgently needed

Method used

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  • Alkaloid compound in purslane herb and extraction and separation method thereof
  • Alkaloid compound in purslane herb and extraction and separation method thereof
  • Alkaloid compound in purslane herb and extraction and separation method thereof

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Embodiment 1

[0029] The invention provides an alkaloid compound, the molecular formula is C 18 h 17 NO 4 , named oleraciamide D, the chemical structure is.

[0030]

[0031] Described a kind of alkaloid compound is called oleraciamide D according to structure, and table 1 is the NMR data of this a kind of alkaloid compound: 1 H-NMR with 13 C-NMR in MeOD.

[0032] Table 1: NMR data of the new alkaloid compound oleraciamide D of the present invention.

[0033]

[0034]

[0035] The structure identification and deduction of an alkaloid compound oleraciamide D of the present invention.

[0036] Oleraciamide D: Yellow powder, easily soluble in methanol, insoluble, slightly soluble in water. After spotting the sample on the silica gel thin-layer plate, the spots of the dilute potassium bismuth iodide test solution appear orange-yellow, suggesting that the compound is an alkaloid component. UV(MeOH)λ max :320nm, IRν N-H 3415,ν C＝O 1670, v C＝C 1634, 1594, v C-N 1515, ν C-O 14...

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicines, and in particular relates to a novel alkaloid compound extracted, separated and identified from purslane herb and an extraction and separation method thereof. The molecular formula of the novel alkaloid compound is C18H17NO4, and the name is oleraciamide D. The invention further provides the extraction and separation method for the novel alkaloid compound, which sequentially adopts water decoction for extraction, extraction in ethyl acetate, silica gel column chromatography, ODS (octadecylsilyl) medium-pressure column, purification by Sephadex LH-20 and liquid phase separation for preparation. The structure is determined as a novel alkaloid compound by adopting UV (ultraviolet), <1>H, NMR (nuclear magnetic resonance), <13>C NMR and two-dimensional NMR spectrum analysis methods. The compound has potential anti-inflammatory and neuroprotection activity and the like, moreover, the preparation method is provided, and a primer and a theoretical basis are provided for the development of new medicines and new ingredients.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to an alkaloid compound extracted, separated and identified from purslane medicinal material and its extraction and separation method, especially the alkaloid compound in purslane and its extraction and separation method. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane likes fertile soil, is resistant to drought and waterlogging, has strong vitality, is widely distributed, and is rich in resources, and it is more common in Northeast my country. Purslane can be used as both medicine and food, and it is one of the wild plants with the same origin of medicine and food designated by the Ministry of Health of my country. The 2015 edition of "The Pharmacopoeia of the People's Republic of China" records that the dried aerial part of pursla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D211/86A61P29/00A61P25/00
CPCC07D211/86
Inventor 英哲铭杨关林赵程程英锡相
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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