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Fungus pestalotiopsis extract and application thereof

A technology for the extract of Polychaeta pseudodiscoides, which is applied in the field of applied microbiology, can solve the problems of undiscovered public reports, and achieve the effect of good activity

Active Publication Date: 2017-07-14
YUNNAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Through document search, do not find the public report of the same document as the content of the present invention

Method used

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  • Fungus pestalotiopsis extract and application thereof

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Embodiment 1

[0035] Inoculate the PDA solid medium with Pestalotiopsis sp. GLGS-5 bacterial blocks, and after culturing at 25°C for 20 days, cut the medium together with the bacterial cells into uniform small pieces and put them into conical flasks. Ethyl acetate: methanol: acetic acid = 80:15:5 (V / V / V) mixed solvent soaking and extraction, soaking for 3d and then filtering, repeating the extraction 3 times, merging the supernatant after filtering, and using a rotary evaporator to evaporate to dryness The crude extract was obtained and stored at 4°C for future use.

[0036] The inhibitory effect of the solid fermented extract of Pestalotiopsis sp. GLGS-5 on AChE was determined by Ellman method, and the results were expressed in percentage. The final concentration of the sample was 2.67mg / mL.

[0037] Table 1 AChE inhibition rate

[0038] sample TA Extract Concentration (mg / ml) 0.066 2.67 Inhibition rate(%) 60.58 61.8 Inhibitory activity ++ ++

[0039...

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Abstract

The invention relates to a fungus pestalotiopsis extract and an application thereof and belongs to the field of applied microbiology. The fungus pestalotiopsis extract is obtained through the steps of fungus strain selection and preparation of a pestalotiopsis (Pestalotiopsis sp.) GLGS-5 extract. The fungus strain is pestalotiopsis (Pestalotiopsis sp.) GLGS-5; the strain GLGS-5 is preserved in a Common Microorganism Center of the China Committee for Culture Collection of Microorganisms on January 9, 2017; the preservation unit address is the Institute No.3, of Microbiology of Chinese Academy No.1 of Sciences, West Beichen Road, Chaoyang District of Beijing; and the preservation number is CGMCC No.13577. The fungus pestalotiopsis extract is applied to preparation of an acetylcholin esterase inhibitor. The fungus pestalotiopsis extract has the beneficial effects that the pestalotiopsis (Pestalotiopsis sp.) GLGS-5 solid fermentation extract is good in activity, the inhibition rate on AChE reaches 61.8% and the fungus pestalotiopsis extract can be applied to preparation of the acetylcholin esterase inhibitor.

Description

[0001] Technical field: [0002] The invention relates to an extract of the fungus Trichosporum pseudodiscoides and its application, belonging to the field of applied microbiology. [0003] Background technique: [0004] Alzheimer's disease (Alzheimer's disease, AD), also known as senile dementia, is a neurodegenerative disease of the central nervous system with insidious onset, manifested as a chronic progressive process, and is a common age-related disease. one of the diseases. Following cardiovascular disease, cancer and stroke, AD has become another major killer that threatens the health of the elderly, bringing great suffering to patients and a very heavy burden on patients' families and society. In the study of the pathogenesis of Alzheimer's disease, the lack of cholinergic theory believes that the lack of neurotransmitter-acetylcholine in the brain of patients with Alzheimer's disease is the key cause of AD disease. The lack of acetylcholine leads to cognitive decline...

Claims

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Application Information

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IPC IPC(8): C12P1/02C12Q1/46C12R1/645
CPCC12P1/02C12Q1/46C12N1/145C12R2001/645
Inventor 赵沛基柳成莽张克勤李国红
Owner YUNNAN UNIV
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