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Application of cyanoacrylate compound on treatment of human and animal fungal infectious diseases

A technology of cyanoacrylates and compounds, applied in the field of infectious human and animal diseases, can solve the problems of no literature reports on the activity of medicine and veterinary drugs

Active Publication Date: 2017-07-28
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far no literature has reported its medicinal and veterinary activity, especially its use in the treatment of fungal infectious human and animal diseases

Method used

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  • Application of cyanoacrylate compound on treatment of human and animal fungal infectious diseases

Examples

Experimental program
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Effect test

preparation Embodiment

[0021] 1. 1% ethyl 2-cyano-3-amino-3-phenylacrylate (cyanostrobin) eye drops and flushing solution

[0022] 2-cyano-3-amino-3-phenylacrylate ethyl ester (cyclostrobin) 1% (w / w), Tween 20 0.5% (w / w), mannitol 12.5% ​​(w / w ), supplemented with 100% normal saline, and prepared 10 mg / ml cyclostrobin eye drops and flushing solution according to conventional methods.

[0023] 2. 10% (w / w) 2-cyano-3-amino-3-phenylacrylate methyl ester immediate release tablet

[0024] 2-Cyano-3-amino-3-phenylacrylate methyl ester 10% (w / w), palmitoylcarnitine 62.1% (w / w), sorbitol 5%, mannitol 5.6% (w / w ), glycerol monostearate 2.7%, sodium stearyl fumarate 0.6% (w / w), compressible sugar and starch 10%, microcrystalline cellulose 4%, prepared by conventional methods 17 (w / w w) Cyclostrobin immediate release tablet.

[0025] 3. 1.5% (w / w) 2-cyano-3-amino-3-phenyl propyl acrylate ointment

[0026] Propyl 2-cyano-3-amino-3-phenylacrylate 1.5% (w / w), stearyl alcohol 7.8% (w / w), sodium benzoate 2.6% (...

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Abstract

The invention relates to application of a cyanoacrylate compound on the treatment of human and animal infectious diseases caused by fungus, particularly human and animal diseases such as skin diseases, keratitis, keratohelcosis, endophthalmitis, osteomyelitis, arthritis, sinus infection, onychomycosis, mycetoma and surgery or burning process infection caused by fusarium.

Description

[0001] Technical field: [0002] The invention relates to the field of treating human and animal diseases caused by fungi, in particular to the application of cyanoacrylate compounds in treating infectious human and animal diseases caused by fungi. [0003] Background technique: [0004] In the past 30 years, the cases of human and animal skin caused by fungal infections have increased sharply, which has led to a more urgent need for new antifungal agents. The drugs currently used to treat fungal infections include amphotericin B, flucytosine, voriconazole, etc. . Amphotericin B is limited by infusion-related reactions and nephrotoxicity, and voriconazole is insurmountable because of its solubility, which limits its use. Therefore, it is necessary to develop new antifungal drugs for the treatment of skin diseases. [0005] Cyanoacrylate compounds refer to 2-cyano-3-amino-3-phenylacrylate methyl ester and 2-cyano-3-amino-3-phenylacrylate ethyl ester whose molecular targets are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/277A61P31/10A61P17/00A61P27/02A61P19/00A61P19/02A61P11/02
Inventor 周明国段亚冰王建新侯毅平周泽华李美霞
Owner NANJING AGRICULTURAL UNIVERSITY
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