Application of cyanoacrylate compound on treatment of human and animal fungal infectious diseases

Abstract

The invention relates to application of a cyanoacrylate compound on the treatment of human and animal infectious diseases caused by fungus, particularly human and animal diseases such as skin diseases, keratitis, keratohelcosis, endophthalmitis, osteomyelitis, arthritis, sinus infection, onychomycosis, mycetoma and surgery or burning process infection caused by fusarium.

Description

[0001] Technical field:

[0002] The invention relates to the field of treating human and animal diseases caused by fungi, in particular to the application of cyanoacrylate compounds in treating infectious human and animal diseases caused by fungi.

[0003] Background technique:

[0004] In the past 30 years, the cases of human and animal skin caused by fungal infections have increased sharply, which has led to a more urgent need for new antifungal agents. The drugs currently used to treat fungal infections include amphotericin B, flucytosine, voriconazole, etc. . Amphotericin B is limited by infusion-related reactions and nephrotoxicity, and voriconazole is insurmountable because of its solubility, which limits its use. Therefore, it is necessary to develop new antifungal drugs for the treatment of skin diseases.

[0005] Cyanoacrylate compounds refer to 2-cyano-3-amino-3-phenylacrylate methyl ester and 2-cyano-3-amino-3-phenylacrylate ethyl ester whose molecular targets are...

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