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Application of allicin in preparation of anti-saccharomycetes drugs

A technology of allicin and yeast, applied in the field of medicine, can solve problems such as no report on the application of allicin

Active Publication Date: 2021-07-13
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there have been reports on the chemical synthesis and structural identification of allicin, but there is no report on the application of allicin in vivo and in vitro against yeasts such as cryptococcus and candida

Method used

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  • Application of allicin in preparation of anti-saccharomycetes drugs
  • Application of allicin in preparation of anti-saccharomycetes drugs
  • Application of allicin in preparation of anti-saccharomycetes drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Synthesis of allicin and product determination.

[0037] Alliin-alliinase Weigh 290mg and 580mg of alliinin according to the mass ratio of 1:2, put them in 10ml measuring bottles, add water to dissolve and dilute to the scale, transfer the allininase solution to a 50ml conical flask with a stopper , quickly add the alliin solution to the allinase solution, mix well, and react at room temperature for 30 minutes. Precisely pipette 0.5ml of the reaction solution into a 25ml measuring bottle, add 15ml of methanol, add 1.0ml of internal standard solution, dilute to the mark with 1% formic acid solution, shake well, filter, and obtain. Precisely draw 20 μl of the test solution, inject it into the high-performance liquid chromatograph, and record the chromatogram (see figure 2 ) to calculate the amount of allicin produced (see Table 1).

[0038] Table 1 Allicin Content Determination Results

[0039]

[0040] Note: A x Represents the peak area of ​​the test solution, A ...

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Abstract

The invention provides application of allicin in preparation of anti-saccharomycetes drugs, and relates to the technical field of medicines. Experiments show that the allicin has a good antibacterial effect on cryptococcus and candida, and the allicin combined with the antifungal drug also has good antibacterial activity on cryptococcus and candida. Experiments also show that allicin achieves a bacteriostatic or bactericidal effect by destroying capsules or cell walls or cell membranes of cryptococcus. The allicin has better activity against cryptococcus in vivo and in vitro. The allicin preparation can be used as a medicine which is safe, effective, small in toxic and side effects and low in price and is used for clinically treating fungal infectious diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of allicin in the preparation of anti-yeast medicine. Background technique [0002] In recent years, with the increase in the incidence of fungi, more than 300 million people in the world have been affected by severe fungal diseases. The pathogenic fungi include common yeasts such as Cryptococcus and Candida. Among the fungal diseases, the incidence of Candida ranks second, and the incidence of Cryptococcus ranks third. However, the current clinical treatment of fungal diseases is limited and expensive, including only polyenes, flucytosines and azoles. Among them, azoles have the lowest bactericidal activity, and the severe side effects and increasing drug resistance of existing antifungal drugs are still problems to be solved at home and abroad. Therefore, there is an urgent need to develop a new type of antifungal drug with high efficiency and low toxicity, wh...

Claims

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Application Information

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IPC IPC(8): A61K31/255A61K45/06A61P31/10C07C381/00A61K31/7048A61K31/4196
CPCA61K31/255A61K45/06A61P31/10C07C381/00A61K31/7048A61K31/4196A61K2300/00
Inventor 叶枫李征途李准李少强占扬清林烨李新霞史荣梅刘睿婷
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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