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A composition for lowering blood fat, its preparation method and application

A composition and blood lipid-lowering technology, which is applied in the direction of drug combination, non-active ingredients of polymer compounds, medical preparations of non-active ingredients, etc., can solve the problems of undisclosed blood-lipid-lowering health products

Active Publication Date: 2020-11-17
SHANGHAI TAO SHENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] It is disclosed in the prior art that carboxymethyl chitosan has the purposes of moisture absorption, moisturizing and bacteriostasis, but there is no disclosure of its application for the preparation of health care products with hypolipidemic properties.

Method used

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  • A composition for lowering blood fat, its preparation method and application
  • A composition for lowering blood fat, its preparation method and application
  • A composition for lowering blood fat, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] In this embodiment, carboxymethyl chitosan with a number average molecular weight of 2000 was prepared.

[0034] The carboxymethyl chitosan raw material with higher number average molecular weight is degraded with hydrogen peroxide, the number average molecular weight of the carboxymethyl chitosan raw material with higher number average molecular weight is 30W, and the carboxymethyl substitution degree is 0.8~1.3, Wherein, O means that the carboxymethyl substitution degree is 0.7-1.0, and the N-position substitution degree is not more than 0.3.

[0035]The process of hydrogen peroxide degradation is: adding hydrogen peroxide to carboxymethyl chitosan with higher number-average molecular weight under stirring conditions for degradation reaction, adding alkali during the degradation reaction to make the pH of the reaction system be 8.0, until the viscosity of the reaction system is Add sodium sulfite to stop the reaction at 80-120cp, and stop the reaction when the viscosi...

Embodiment 2

[0038] Carboxymethyl chitosan with a number average molecular weight of 8000 was adopted in the present embodiment.

[0039] The carboxymethyl chitosan raw material with higher number average molecular weight is degraded with hydrogen peroxide, the number average molecular weight of the carboxymethyl chitosan raw material with higher number average molecular weight is 40W, and the carboxymethyl substitution degree is 0.8~1.3, Wherein, O means that the carboxymethyl substitution degree is 0.7-1.0, and the N-position substitution degree is not more than 0.3.

[0040] The process of hydrogen peroxide degradation is: adding hydrogen peroxide to carboxymethyl chitosan with higher number-average molecular weight under agitation to carry out the degradation reaction, adding alkali during the degradation reaction to make the pH of the reaction system be 8.5 until the viscosity of the reaction system is Add sodium sulfite at 100cp to stop the reaction. In the degradation reaction, the...

Embodiment 3

[0043] Carboxymethyl chitosan with a number average molecular weight of 15,000 is used in this embodiment.

[0044] The carboxymethyl chitosan raw material with higher number average molecular weight is degraded with hydrogen peroxide, the number average molecular weight of the carboxymethyl chitosan raw material with higher number average molecular weight is 55W, and the carboxymethyl substitution degree is 0.8~1.3, Wherein, O means that the carboxymethyl substitution degree is 0.7-1.0, and the N-position substitution degree is not more than 0.3.

[0045] The process of hydrogen peroxide degradation is: adding hydrogen peroxide to carboxymethyl chitosan with higher number-average molecular weight under agitation to carry out the degradation reaction, adding alkali during the degradation reaction to make the pH of the reaction system be 8.5 until the viscosity of the reaction system is At 90cp, sodium sulfite was added to stop the reaction. In the degradation reaction, the re...

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Abstract

The invention discloses a composition for reducing blood fat. The composition is characterized by comprising the following raw materials in parts by weight: 100-120 parts of carboxymethyl chitosan, 10-35 parts of taurine, 10-20 parts of cyclodextrin, 20-35 parts of sodium alginate and 5-15 parts of magnesium stearate. The tablet contains the cyclodextrin and the taurine as absorption promoters, and the sodium alginate as a binder and a disintegrating agent, and interacts with the carboxymethyl chitosan which has a blood fat reducing effect and is easy to disintegrate, so that the finally obtained composition has a better blood fat reducing effect; and the tablet can also be combined with other antilipemic drugs, so that the usage amount and the side effects of common antilipemic drugs are greatly reduced, the treatment effect is obvious and other complications can be significantly reduced or eliminated.

Description

technical field [0001] The invention relates to a composition for lowering blood fat, in particular to a composition for lowering blood fat prepared by carboxymethyl chitosan. Background technique [0002] Carboxymethyl chitosan is a water-soluble chitosan derivative with many properties, such as strong antibacterial, fresh-keeping effect, and an amphoteric polyelectrolyte. It has many applications in cosmetics, fresh-keeping, medicine, etc. It is also one of the chitosan derivatives that have been studied more in recent years. [0003] The carboxymethyl group of carboxymethyl chitin is substituted on the C6-OH of the sugar residue, and a small amount of carboxymethyl group is substituted on the C3-OH, resulting in O-carboxymethyl chitin. In chitosan, the carboxymethyl group will be substituted on both -OH and -NH to generate O-carboxymethyl and N-carboxymethyl chitosan. The actual substitutions are: C6 -O-carboxymethyl, C2-N-carboxymethyl, C3-O-carboxymethyl, C6-O, C2-N-c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61K9/20A61K47/20A61K47/40A61K47/36A61P3/06
CPCA23V2002/00A61K9/2013A61K9/205A61K31/722C08B37/003A23V2200/3262A23V2250/0644A23V2250/5112A23V2250/1614A23V2250/161
Inventor 徐宇帆
Owner SHANGHAI TAO SHENG BIOTECH CO LTD
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