Novel method for preparing calamine and nitrofurazone pharmaceutical composition
A technology of nitrofurazone and calamine is applied in directions such as drug combination, drug delivery, and pharmaceutical formulation, which can solve the problems of inconvenient operation and control, easy moisture absorption of medicinal powder, easy generation of dust, etc. The effect of drug efficacy and prolongation of stratification time
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[0036] Example 1:
[0037] The composition of raw materials:
[0038] Material name Dosage (unit: kg) Calamine 12.0kg Zinc oxide 12.0kg Nitrofurazone30g Sodium carboxymethyl cellulose375g glycerin7500ml purified water Add to total 150,000ml
[0039] Preparation:
[0040] (1) Pour sodium carboxymethyl cellulose into a proper amount of purified water. When it meets water to form agglomerates, use a stir bar to disperse the "large clusters" into small pieces;
[0041] (2) Add nitrofurazone to the solution (1), stir it slightly to disperse it, and do not form agglomerates;
[0042] (3) Adjust the colloid mill to the "0.01" point, add a small amount of purified water, start the colloid mill to make the purified water circulate in the colloid mill, add the liquid obtained in (2) to the colloid mill, circulate for 3-5 minutes, and release;
[0043] (4) Stir calamine powder, zinc oxide powder, glycerin, and an appropriate amount of purified water, add them to the solution (3), stir to ...
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[0046] Example 2:
[0047] The composition of raw materials:
[0048]
[0049]
[0050] Preparation:
[0051] (1) Pour sodium carboxymethyl cellulose into a proper amount of purified water. When it meets water to form agglomerates, use a stir bar to disperse the "large clusters" into small pieces;
[0052] (2) Add nitrofurazone to 1 / 2 of the dispersed sodium carboxymethylcellulose slurry, and stir slightly;
[0053] (3) Adjust the colloid mill to the "0.01" point, add a small amount of purified water, start the colloid mill to make the purified water circulate in the colloid mill, add the liquid obtained in (2) to the colloid mill in batches, each cycle is 3-5 minutes, release;
[0054] (4) Take calamine powder and zinc oxide powder, add glycerin, 1 / 2 sodium carboxymethyl cellulose pulp and an appropriate amount of purified water, stir, stir slightly, and not form agglomerates;
[0055] (5) Add the mixed liquid obtained in (4) to the colloid mill in batches, circulate for 2-3 minutes eac...
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