Compound mango leaf extract anti-inflammatory health care toothpaste and preparation method thereof

A mango leaf and extract technology, applied in dentistry, drug combination, pharmaceutical formula and other directions, can solve the problems of low bioavailability, unsatisfactory clinical trial effect, etc., and achieve the effect of improving oral inflammation

Active Publication Date: 2020-07-21
杭州怡辉跃康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the extremely low bioavailability of mangiferin to the human body, the clinical trials of these oral preparations are not ideal

Method used

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  • Compound mango leaf extract anti-inflammatory health care toothpaste and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A. Preparation of raw materials: Fresh mango leaves are used as raw materials, dried naturally or dried at 50°C, and crushed through a 20-mesh sieve.

[0038] B. Ester extraction and impurity removal: Weigh 1000g of mango leaf powder, add 3L of ethyl acetate, seal and soak for 5h, shake at room temperature for 15min, and filter; the extraction is repeated 4 times, and the green of the extract basically disappears.

[0039] C. Methanol extraction: Take the residue extracted in step B, add 2.5L methanol, seal and soak at 30°C for 5h, stir and extract at 55°C for 0.5h, filter while hot, and extract 5 times repeatedly. Combine the extracts and precipitate at room temperature 9h, finely filter with 200 mesh filter.

[0040] D. Concentration and washing: Concentrate the filtrate of step C by vacuum rotary evaporation at 50°C to obtain a concentrated extract of about 50g, add 150mL methanol, stir and wash at 55°C for 10 minutes, let cool, filter with a 200 mesh filter, and wash repea...

Embodiment 2

[0042] A. Preparation of raw materials: Fresh mango leaves are used as raw materials, dried naturally, and crushed through a 30-mesh sieve.

[0043] B. Ester extraction and impurity removal: Weigh 1000g of mango leaf powder, add 4L of ethyl acetate, seal and soak for 4h, shake at room temperature for 10min, and filter; the extraction is repeated 3 times, and the green of the extract basically disappears.

[0044] C. Methanol extraction: Take the residue extracted in step B, add 4L of methanol, seal and soak at 40°C for 4h, stir and extract at 60°C for 0.5h, filter while hot, extract 4 times repeatedly, combine the extracts, and precipitate at room temperature for 10h , Finely filter with 200 mesh filter.

[0045] D. Concentration and washing: Concentrate the filtrate of step C by vacuum rotary evaporation at 65°C to form a concentrated extract, add 200 mL of methanol, stir and wash at 50°C for 20 minutes, let cool, filter with a 200 mesh filter, and wash 5 times repeatedly, filter th...

Embodiment 3

[0047] A. Raw material preparation: Fresh mango leaves are used as raw materials, dried at 65°C, and crushed through a 40 mesh sieve.

[0048] B. Ester extraction and impurity removal: Weigh 1000g of mango leaf powder, add 2L of ethyl acetate, seal and soak for 6h, shake at room temperature for 20min, and filter; extraction is repeated 5 times, and the green of the extract basically disappears.

[0049] C. Methanol extraction: Add 2L methanol to the residue after extraction in step B. After sealing and soaking at 30°C for 6 hours, stirring and extracting at 60°C for 1 hour, filtering while hot, and extracting 6 times repeatedly. Combine the extracts and precipitate at room temperature for 12 hours. Finely filter with a 200 mesh filter.

[0050] D. Concentration and washing: Concentrate the filtrate of step C by vacuum rotary evaporation at 65°C to form a concentrated extract, add 130 mL of methanol, stir and wash at 50°C for 20 minutes, let cool, filter with a 200 mesh filter, and wa...

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Abstract

The invention belongs to the field of medical care and daily chemical products, and particularly relates to compound anti-inflammation healthcare toothpaste with mango leaf extract and a method for preparing the compound anti-inflammation healthcare toothpaste. The mango leaf extract is used as a main active anti-inflammation component of the compound anti-inflammation healthcare toothpaste. The compound anti-inflammation healthcare toothpaste comprises main active components including, by weight, 1-2 parts of mango leaf extract, 3-5 parts of salicylic acid and 8-12 parts of menthol. The content of mangiferin in the mango leaf extract is 60%-70%. The compound anti-inflammation healthcare toothpaste and the method have the advantages that excellent effects of preventing and treating oral inflammation such as oral ulcer and gingivitis can be realized by the compound anti-inflammation healthcare toothpaste; the mango leaf extract, the salicylic acid and the menthol are matched with corresponding auxiliary materials to obtain the compound anti-inflammation healthcare toothpaste, accordingly, daily oral cleaning requirements can be met, and obvious effects of improving the oral inflammation such as the oral ulcer and the gingivitis further can be realized by the compound anti-inflammation healthcare toothpaste.

Description

Technical field [0001] The invention belongs to the field of medical care and daily chemical products, and specifically relates to a compound mango leaf extract anti-inflammatory health toothpaste with mango leaf extract as the main active anti-inflammatory component and a preparation method thereof. Background technique [0002] Mango (Mangifera indica L.) is a common tropical fruit in southern my country. The planting area of ​​mangoes in Panxi, Sichuan has reached more than 300,000 mu, with high yield and good quality. It occupies the domestic late-ripening mango market, and the mango industry has become the leading industry in local agriculture. The inventor’s long-term determination and analysis show that the content of mangiferin in mango leaves in Panxi area is as high as 2-8%, which is much higher than that in other plants such as Zhimu, and much higher than that in mango leaves in other producing areas in my country. The content of mangiferin. [0003] Mangiferin, also kn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/73A61K8/60A61K8/46A61K8/368A61K8/365A61K8/36A61K8/34A61K8/24A61Q11/00A61K36/22A61P1/02A61K31/60A61K31/045
CPCA61K8/24A61K8/34A61K8/345A61K8/36A61K8/365A61K8/368A61K8/463A61K8/60A61K8/73A61K8/731A61K8/97A61K31/045A61K31/60A61K36/22A61K2800/524A61Q11/00A61K2300/00
Inventor 尚远宏韦会平韩洪波田金凤
Owner 杭州怡辉跃康科技有限公司
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