Compound, protein, preparation method of compound, and preparation method of protein

A protein and complex technology, which is applied in the field of protein and their preparation and complex, can solve the problems of short timeliness and inability to realize oral administration, and achieve the effect of improving purity, strong stability, safety and quality research convenience
CN107033247AInactive Publication Date: 2017-08-11天津博锐生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
天津博锐生物科技有限公司
Publication Date
2017-08-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a compound, a protein, a preparation method of the compound, and a preparation method of the protein, and relates to the technical field of biomedicines. The compound has high stability, can be orally administered on the basis of the long-acting blood sugar lowering function of glucagon-like peptide-1, lays a foundation for the further development of diabetes related drugs, and deserves subsequent continuous development. The preparation method of the protein is characterized in that physical deoxidation is carried out at 75-85 DEG C, so the purity of the protein is greatly increased; and the protein is prepared through using the preparation method of the protein, and the purity reaches 80% or above. A protein purification technology provided by the present invention can remove the heat toxin proteins and nucleic acid substances introduced by yeast fermentation, and brings convenience for the researches on the safety and the quality of the protein used as a medicinal preparation in the later application stage.
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Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to a complex, a protein and a preparation method of the two. Background technique

[0002] Diabetes mellitus (DM) is a metabolic disease characterized by relative or absolute insufficiency of insulin. Relative or absolute insufficiency of insulin leads to hyperglycemia, which in turn leads to metabolic disorders of the three major nutrients, ultimately affecting the normal physiological functions of patients and causing complications. Diabetes is increasing worldwide and is expected to reach 439 million by 2030.

[0003] Glucagon-like peptide-1 is a 37 amino acid peptide secreted by intestinal L-cells in response to food intake. Glucagon-like peptide-1 has been found to stimulate insulin secretion (insulinotropic activity), resulting in cellular uptake of glucose and a decrease in serum glucose levels. However, glucagon-like peptide-1 has very low activity and a serum half-lif...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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