Screening chip for screening monoclonal antibodies
A monoclonal antibody, chip technology, applied in measurement devices, instruments, scientific instruments, etc., can solve the problem of limited application range of biochips, achieve good mechanical properties and dimensional stability, reduce processing time, and reduce confusion between samples Effect
Inactive Publication Date: 2017-08-11
深圳源广安智能科技有限公司
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Problems solved by technology
[0003] The existing biochips are not widely used, and most of them are limited to the direct use of biochips for the detection of target substances. Therefore, it is urgent to develop a biochip that can be applied to other fields
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[0016] The present invention will be further described in conjunction with the following examples.
[0017] A screening chip for screening monoclonal antibodies, such as figure 1 As shown, it includes base-10, membrane structure-20, chemical modification layer-30, molecular probe layer-40, left section, right section-11, middle section-12, groove 13; the base is 3 sections Formula structure, divided into left section, middle section and right section; the surface of the middle section is provided with a surface structure, and the surface structure is a membrane structure; there is also a chemical modification layer above the membrane structure; molecules are fixed on the surface of the chemical modification layer In the probe layer, the molecular probe array is 6 rows×8 columns, and the distance between adjacent molecular probes in each row and each column is 1-3mm.
[0018] Preferably, the thickness of the base is 2-4mm, the length of the middle section is 1 / 2 of the total l...
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Abstract
The invention specifically discloses a screening chip for screening monoclonal antibodies, including a base, a membrane structure, a chemical modification layer, a molecular probe layer, a left section, a right section, a middle section, and a groove; the base is 3 Segment structure, divided into left section, middle section and right section; the surface of the middle section is provided with a surface structure, and the surface structure is a membrane structure; there is also a chemical modification layer above the membrane structure; the surface of the chemical modification layer is fixed with Molecular probe layer, the molecular probe array is 6 rows×8 columns. The left section and the right section of the base of the present invention use engineering plastics with better plasticity, which can withstand certain external forces, have good mechanical properties and dimensional stability, and can maintain their excellent performance at high and low temperatures; no matter what material is used in the middle section , the left section and the right section can be firmly combined with the middle section to increase the service life; the biochip of the present invention has a reasonable shape and structure design, combined with ergonomics, and has a better detection operation experience and a good hand feel.
Description
technical field [0001] The invention relates to the technical field of biochips, in particular to a screening chip for screening monoclonal antibodies. Background technique [0002] Biochip is a brand-new biological detection technology developed rapidly in the late 1980s. It uses microelectronic lithography technology to construct a micro-biochemical analysis system with a large number of probe molecular lattices on the surface of a square centimeter solid phase carrier. , to achieve rapid, accurate and high-throughput detection of cells, nucleic acids, proteins, carbohydrates and other biomolecules. After long-term research and improvement, the current biochip is mainly developing in the direction of high throughput, miniaturization and automation. Generally speaking, biochips use solid microplates or microbeads as probe molecule carriers to construct hundreds to tens of thousands of microarrays on a centimeter-scale chip in parallel, and use probe molecules at the molecu...
Claims
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CPCG01N33/577
Inventor 孟玲
Owner 深圳源广安智能科技有限公司