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Use of lipophilic salicylic acid derivatives

A technology of uses, compounds, applied in the field of beauty, able to solve the problems of loose skin, dryness, loss of firmness, etc.

Pending Publication Date: 2017-08-18
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Likewise, the replacement of collagen fibers decreases with age, which leads to thinning of the dermis and loose skin, leading to loss of firmness, which leads to dry, saggy skin

Method used

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  • Use of lipophilic salicylic acid derivatives
  • Use of lipophilic salicylic acid derivatives
  • Use of lipophilic salicylic acid derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0167] Example 1: Preparation of Compounds of the Invention

[0168] Compounds (A'), (F) and (E) according to the present invention are prepared according to the methods described below.

[0169] 1.1. Preparation of compound (A')

[0170]

[0171] In the presence of 12 g (0.0057 mol) of Pd / C (10% by weight), 117 g (0.33 mol) of an anacardic acid mixture of compounds A', B', C' and D' in 1 liter of EtOH was placed in 2 liter glass hydrogenation vessel. After purging 3 times with nitrogen and then with hydrogen, the medium is stirred under 2 bar of hydrogen at ambient temperature for 20 hours. Proton NMR spectra generated from an aliquot after purging 3 times with nitrogen indicated that the reaction was complete. Filter the media through celite and rinse the celite with ethanol. The filtrate was concentrated and then dried under vacuum at 40 °C to give the desired product (113 g, 98% yield) in the form of a light gray solid.

[0172] NMR and LC / MS analysis confirmed...

Embodiment 2

[0181] Example 2: anti-aging effect

[0182] Compared with 5% LHA (lipid hydroxy acid, 2-hydroxy-5-octanoylbenzoic acid) in ethanol, by the protein collagen III, membrane transglutaminase (MTG), filaggrin and laminin Immunolabelling, the anti-aging effect of 5% compound (F) in water obtained in particular according to the method described above was evaluated in vitro.

[0183] 2.1: plan

[0184] Preparation of explants

[0185] One hundred and eleven explants with a diameter of approximately 10 mm were prepared from abdominoplasty in a 66-year-old Caucasian woman. These explants were kept viable.

[0186] product application

[0187] On D1 day, explants were placed on grids in 2 ml medium.

[0188] On days D0, D1, D4, D6 and D8, the product was applied topically at the desired concentration (in the proportion of 2 mg per explant) and spread using a small spatula.

[0189] Control batches of explants received no treatment other than medium replacement.

[0190] H...

Embodiment 3

[0244] Example 3: Epidermal renewal and barrier effect

[0245] The effects of compounds (A') and (F) (especially compounds (A') and (F) obtained according to the method described above) on epidermal renewal and skin The impact of the barrier effect.

[0246] Transglutaminases are aminoacyltransferases. Transglutaminase is a form of polymeric protein that is generally insoluble in water. These biopolymers are the basis for creating barriers and stabilizing structures. Thus, transglutaminase is particularly involved in the synthesis of skin and hair. In particular, transglutaminase 3 (TGM3) is an epidermal transglutaminase (see Griffin et al., Biochem. J. 2002, vol. 368, 377-396).

[0247] 3.1: plan

[0248] Human epidermal keratinocytes were incubated for 24 hours in the presence or absence (control) of compound (A') or (F). At the end of the incubation, total RNA was extracted and quantified. then according to The incorporation technology of Green (Qiagen), usin...

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Abstract

The present invention relates to the cosmetic use of at least one compound of formula (I), of at least one of its salts of formula (II) or of a mixture comprising at least one compound of formula (I) and at least one compound of formula (II): as agent(s) intended to prevent and / or treat cutaneous signs of ageing, A non-therapeutic cosmetic method for preventing and / or treating cutaneous signs of ageing using these compounds is also targeted.

Description

technical field [0001] The present invention relates to the field of cosmetology, and more particularly to the use of certain salicylic acid derivatives as agents for preventing and / or treating symptoms of skin aging. [0002] More specifically, the object of the present invention is to provide the use of the derivatives for the prevention and / or treatment of wrinkles and fine lines, in particular of the face and / or body, more particularly of the face and / or Wrinkles and fine lines on the neck. [0003] The invention also relates to the use of these derivatives to combat dry, sagging and / or thinning skin, in particular of the face and / or body, especially of the face and / or neck. Background technique [0004] Human skin is mainly composed of two compartments, the superficial compartment (epidermis) and the deep compartment (dermis), whose union is ensured by the epidermal junction. [0005] The natural human epidermis is mainly composed of three types of cells, keratinocyte...

Claims

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Application Information

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IPC IPC(8): A61K8/368A61Q19/08
CPCA61K8/368A61Q19/08A61K8/44A61Q19/00
Inventor 莫德·布罗萨特露西·图尔尼尔-库蒂里耶
Owner LOREAL SA