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Blood test chip and manufacture method thereof

A manufacturing method and chip technology, applied in the field of medical equipment, can solve the problems of high cost of use, low detection efficiency, single detection index, etc., and achieve the effects of convenient detection, shortening interval time, and eliminating blood sampling.

Active Publication Date: 2017-08-22
ZHEJIANG DAPU BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a low-cost, easy-to-use, accurate and fast blood test chip for the existing blood test equipment with single detection index, high cost of use, and low detection efficiency.

Method used

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  • Blood test chip and manufacture method thereof
  • Blood test chip and manufacture method thereof
  • Blood test chip and manufacture method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Such as Figure 1~3 As shown, a blood test chip includes a carrier substrate 1, a conductive base layer 2 arranged on the carrier substrate 1, and an insulating adhesive layer 3 covering the conductive base layer 2; wherein the carrier substrate 1 is a silicon substrate, graphite An vinyl sheet or a silicon carbide substrate; the insulating adhesive layer 3 is provided with a probe through hole 4, and the probe through hole 4 is provided with a nano-metal probe 5 protruding from the surface of the insulating adhesive layer 3, and the nano-metal probe 5 includes a metal probe The needle body 51 and the thorn-like protrusion 52 distributed on the surface of the metal probe body 51, the thorn-like protrusion 52 and its surroundings are attached with antibody molecules 53 for detecting pathogens, and the antibody molecules 53 are DNA molecules, RNA molecules and immobilized enzyme molecules at least one of the

[0037] The metal probe body 51 includes a metal post 511 disp...

Embodiment 2

[0047] This embodiment provides a method for manufacturing the blood test chip described in Embodiment 1, which includes the following steps:

[0048] Step 1: Cleaning the surface of the carrier substrate 1, then coating the conductive base layer 2 and the photoresist layer in sequence, then exposing and developing under the irradiation of ultraviolet light, and using a metal etchant to remove the unexposed conductive base layer 2 , to form the required circuit pattern; wherein, the conductive base layer 2 is a conductive metal layer, preferably a gold layer or a copper layer, and the photoresist layer is preferably SU-8 photoresist;

[0049] Step 2, peeling off the photoresist layer, cleaning and drying, and then coating the insulating adhesive layer 3, and punching through the insulating adhesive layer 3 to obtain a chip substrate containing the probe through hole 4; wherein the insulating adhesive Layer 3 is a phenolic resin layer, an epoxy resin layer, a polyimide resin la...

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Abstract

The invention relates to the technical field of medical devices, in particular to a blood test chip and a manufacture method thereof. The blood test chip comprises a carrier substrate, a conductive base layer arranged on the carrier substrate, and an insulating adhesive layer covering the conductive base layer, wherein a probe through hole is arranged on the insulating adhesive layer, the probe through hole is provided with a nano-metal probe protruding from the surface of the insulating adhesive layer, the nano-metal probe comprises a metal probe body and spinous protrusions on the surface of the metal probe body, antibody molecules detecting pathogens are adhered to the spinous protrusions and surroundings, the antibody molecules are at least one kind of DNA molecules, RNA molecules and immobilized enzyme molecules. Compared with the prior art, the blood test chip disclosed by the invention can give a blood test result within a few minutes or even few seconds, so that a user can know the health condition in time so as to carry out the timely disease prevention or treatment, and compared a conventional blood test in a hospital, the blood test chip greatly reduces the test cost, and makes blood test more convenient and more efficient.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, in particular to a blood test chip and a manufacturing method thereof. Background technique [0002] Blood is an opaque red liquid flowing in the heart and blood vessels, and its main components are plasma, blood cells and platelets. Blood cells are divided into red blood cells and white blood cells. Blood contains various nutrients, such as inorganic salts, oxygen, metabolites, hormones, enzymes and antibodies, which have the functions of nourishing tissues, regulating organ activities and defending against harmful substances. Physiological and pathological changes in various organs of the human body often cause changes in blood components, so blood tests are often used to diagnose diseases after illness. [0003] According to the statistics of the World Health Organization, if cancer patients can be found in the early stage, the cure rate can reach 80%. However, in the early stages...

Claims

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Application Information

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IPC IPC(8): G01N33/536
CPCG01N33/536
Inventor 郭宝煊
Owner ZHEJIANG DAPU BIOTECHNOLOGY CO LTD
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