Preparation method of stable nanometer suspensions of mederate hydrophobic medicine

A nanosuspension, hydrophobic drug technology, applied in pharmaceutical formulations, medical preparations of inactive ingredients, capsule delivery, etc., can solve the problems of high particle load and high stability of particle size that cannot be satisfied at the same time. , to achieve the effect of long dimensional stability, small average particle size and good stability
CN107115296AActive Publication Date: 2017-09-01YANGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
YANGZHOU UNIV
Publication Date
2017-09-01

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Abstract

The invention relates to a preparation method of a nanometer suspensions of a moderate hydrophobic medicine, and belongs to the technical field of production of nanometer medicine agents. The preparation method comprises the following steps of dissolving the moderate hydrophobic medicine and a hydrophobic end functionalizing type amphiphilic block copolymer into an organic solvent which is mutually dissolved into water; quickly jetting and blending the solution and water with certain pH (potential of hydrogen) value, and enabling the medicine and the block copolymer to generate ionizing to produce opposite charges, so as to form a complex, thereby greatly reducing the apparent hydrophobic property of the medicine; instantaneously separating out together with the block copolymer, so as to prepare the nanometer suspensions of the medicine. The nanometer suspensions has the characteristics that the average particle size is small, the medicine carrying amount is overhigh, the size stabilizing time is long, and the single dispersivity is good.
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Description

technical field

[0001] The invention belongs to the technical field of production of nanomedicine. Background technique

[0002] The preparation of nanoscale carriers with stable dimensions over time is a topic of common concern in many fields, especially some nanoscale carriers with ultra-high loading capacity. For example, in the field of pharmaceuticals, more than 40% of newly discovered organic drug small molecules have extremely low water solubility. Most of these hydrophobic drugs had to be abandoned due to the difficulty of administration. People often try to make these small molecules into nano-formulations to improve their dispersibility in water and increase their dissolution rate, thereby increasing their bioavailability.

[0003] For common nanoscale carriers, such as micelles, vesicles, liposomes, etc., although they have good dimensional stability over time, due to the low thermodynamic solubility of hydrophobic drug molecules in the hydrophobic region inside...

Claims

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