Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Apremilast oral solid preparation and preparation method thereof

A technology of solid preparations and fillers, applied in anti-inflammatory agents, pill delivery, pharmaceutical formulations, etc., which can solve problems such as insufficient oral release, low dissolution of apremilast, and complicated operation processes, and achieve stable and reliable quality and reduce The effect of simple production cost and equipment operation

Inactive Publication Date: 2017-09-01
广州艾格生物科技有限公司
View PDF4 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to provide an oral solid preparation of apremilast and its preparation method, which effectively solves the problems of low dissolution of apremilast, insufficient oral release, complex operation process, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Apremilast oral solid preparation and preparation method thereof
  • Apremilast oral solid preparation and preparation method thereof
  • Apremilast oral solid preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～6

[0025] Embodiments 1-6 Apremilast oral solid preparation and preparation method thereof

[0026] The formulations of the oral solid preparations of apremilast in Examples 1-6 are as described in Table 1.

[0027] The formula (unit: g) of the apremilast oral solid preparation of table 1 embodiment 1~6

[0028]

[0029] The preparation method of the Apremilast tablet of above embodiment 1~6 is as follows:

[0030] (1) passing the active ingredient of the drug through a 120-mesh sieve for subsequent use; fillers and disintegrants through a 120-mesh sieve for subsequent use;

[0031] (2) Weighing and premixing: mix the prescribed amount of API with fillers and disintegrants in a mixer;

[0032] (3) add lubricant to above-mentioned mixed powder, tabletting;

[0033] (4) will The powder is formulated into a solution and coated, and the coating temperature is controlled at 38°C to 42°C.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an apremilast oral solid preparation and a preparation method thereof. The invention belongs to the field of pharmaceutical preparations. The apremilast oral solid preparation is prepared by mixing, pressing and coating active components and excipients. The apremilast oral solid preparation comprises medicine active components, a filling agent, a disintegrating agent, a lubricating agent and a coating material. The compressibility and the flowability of the medicine can be improved by using auxiliary materials, and the oral solid preparation with high dissolvability and stable quality can be prepared by a powder direct tabletting process. The preparation method is simple in operation, low in production, high in efficiency, environment-friendly and suitable for industrialized mass production of the apremilast oral solid preparations.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, more specifically, the invention relates to a premilast oral solid preparation with apremilast as an active ingredient and a preparation method thereof. Background technique [0002] The English name of Apremilast is Apremilast, and the chemical name is S-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl)-4-acetylaminoiso Indoline-1,3-dione, the molecular formula is C22H24N207S, the molecular weight is 460.5, and the chemical structural formula is as follows: [0003] [0004] Apremilast is a small molecule phosphodiesterase 4 (PDE4) inhibitor, which can regulate the action of intracellular pro-inflammatory and anti-inflammatory factors, reduce joint swelling and improve the physiological functions of joints. Apremilast was developed by Celgene Biotechnology Company and was approved by the US FDA on March 21, 2014. The trade name is For the treatment of psoriasis and psoriati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/36A61K47/38A61K47/26A61K31/4035A61P17/06A61P19/02A61P29/00
CPCA61K9/2866A61K9/0053A61K9/2018A61K9/2054A61K9/2095A61K31/4035
Inventor 汤文星余思琴谭斌
Owner 广州艾格生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com