Beta-carboline compound and synthetic method and application thereof
A synthesis method and compound technology, applied in the field of medicine, can solve the problems of insufficient expansion research of β-carboline alkaloids, complicated extraction, limited preparation cost, etc., and achieve the effect of significant anti-renal fibrosis activity and good therapeutic effect.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0035] Embodiment 1 structure is as the preparation of the compound shown in formula I
[0036] 1) Dissolve 400 mg (16.6 mmol) of NaH in 1 mL of N, N-dimethylformamide, stir for 10 min, and gradually add 550 mg (2 mmol) of 1-pyridine-6-methoxy-β-carboline, Stir at room temperature for 10 minutes, then add 555 mg (3 mmol) of 3-methylbenzyl bromide dropwise, and continue the reaction at room temperature for about 20 minutes; after the reaction, the product obtained is adjusted to neutrality with 400 ml of ammonia water, extracted with ethyl acetate, and the organic phase is collected , and the solvent was removed under reduced pressure to obtain the crude product of yellow oily liquid;
[0037] 2) The crude product was subjected to silica gel column chromatography using a solvent composed of petroleum ether:ethyl acetate=1000:100 (volume ratio) as an eluent to obtain an orange-yellow powder product (654 mg, yield 85.8%, purity 99.90%).
[0038] The obtained orange-yellow powder...
Embodiment 2
[0044] Embodiment 2 structure is as the preparation of the compound shown in formula I
[0045] Dissolve 200 mg (8.33 mmol) of NaH in 1 mL of N, N-dimethylformamide, stir for 10 min, and gradually add 275 mg (1 mmol) of 1-pyridine-6-methoxy-β-carboline, and stir at room temperature 10min, then add 277.5mg (1.5mmol) of 3-methylbenzyl bromide dropwise, and continue the reaction at room temperature for about 20min; after the reaction, the product obtained is adjusted to neutrality with 400ml of ammonia water, extracted with ethyl acetate, and the organic phase is collected , and the solvent was removed under reduced pressure to obtain the crude product of yellow oily liquid;
[0046] The crude product was subjected to silica gel column chromatography using petroleum ether:ethyl acetate=1000:80 (volume ratio) as the eluent to obtain an orange-yellow powder product (248 mg, yield 65.4%, purity 99.93%).
[0047] The obtained orange-yellow powder product was characterized by NMR and...
Embodiment 3
[0048] Embodiment 3 structure is as the preparation of the compound shown in formula I
[0049] 1) Dissolve 200 mg (8.33 mmol) of NaH in 5 mL of N, N-dimethylformamide, stir for 10 min, and gradually add 275 mg (1 mmol) of 1-pyridine-6-methoxy-β-carboline, Stir at room temperature for 10 min, then add 277.5 mg (1.5 mmol) of 3-methylbenzyl bromide dropwise, and continue the reaction at room temperature for about 20 min; The organic phase was removed under reduced pressure to obtain the crude product of yellow oily liquid;
[0050] 2) The crude product was subjected to silica gel column chromatography using a solvent composed of petroleum ether:ethyl acetate=1000:50 (volume ratio) as an eluent to obtain an orange-yellow powder product (286 mg, yield 76.3%, purity 99.90%).
[0051] The obtained orange-yellow powder product was characterized by NMR and determined to be 1-pyridine-6-methoxy-9-(3-methylbenzyl)β-carboline described in the present invention.
PUM
Property | Measurement | Unit |
---|---|---|
diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com