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Method and Application of Hard Capsule Internal Sealing

A hard capsule and sealing technology, which is applied in the directions of capsule delivery and inactive components of polymer compounds, can solve the problems of filling, liquid leakage, and oxidative degradation of drugs that cannot be used for oxygen-sensitive drugs, so as to avoid the delay of disintegration time. Simple, leak-proof effect

Active Publication Date: 2021-01-15
厦门普罗康客科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing hard capsule filling technology cannot achieve complete sealing, so that oxygen-sensitive drugs will be oxidatively degraded when exposed to air for a long time; filling liquid will leak, so it cannot be applied to liquid or Filling of Oxygen Sensitive Drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0020] S2: Use nitrogen and / or inert gas to carry the sealing liquid, spray it on the inner surface of the capsule cap after atomization, and form a liquid film; wherein, the sealing liquid includes adhesive and solvent ethanol, and the mass fraction of adhesive is 5%~ 70%, the raw material components of the adhesive include povidone; the preparation method of the sealing liquid comprises the following steps: uniformly mixing the adhesive and a solvent to obtain the sealing liquid.

[0021] Preferably, the raw material components of the adhesive include by weight: 20-30 parts by weight of povidone, 6-8 parts by weight of gum arabic, 1-2 parts by weight of hypromellose, and 10-12 parts by weight of gelatin 15-20 parts by weight of methyl-β-cyclodextrin and 4-6 parts by weight of agar; the preparation method of the adhesive comprises the following steps: uniformly mixing all the raw material components to obtain the adhesive.

[0022] S3: Combine the capsule body filled with mat...

Embodiment 1

[0025] The present embodiment provides a method for sealing the inside of a hard capsule, comprising the steps of:

[0026] S1: Separate the capsule body and capsule cap of the hard capsule shell, and then fill the capsule body with fat-soluble solid material.

[0027] S2: Nitrogen gas is used to carry the sealing liquid, which is atomized and sprayed on the inner surface of the capsule cap to form a liquid film; wherein, the sealing liquid includes the adhesive povidone and solvent ethanol, and the mass fraction of the adhesive is 5%; the sealing liquid The preparation method comprises the following steps: uniformly mixing an adhesive and a solvent to obtain a sealing liquid.

[0028] S3: Combine the capsule body filled with materials and the capsule cap with a liquid film, and then heat the combined capsule in hot air at a temperature of 30°C and a wind speed of 0.1m / s until the solvent in the sealing liquid evaporates completely , the capsule seal is intact.

Embodiment 2

[0030] The present embodiment provides a method for sealing the inside of a hard capsule, comprising the steps of:

[0031] S1: Separate the capsule body and capsule cap of the hard capsule shell, and then fill the capsule body with fat-soluble solid material.

[0032] S2: Use an inert gas to carry the sealing liquid, spray it on the inner surface of the capsule cap after atomization, and form a liquid film; wherein, the sealing liquid includes the adhesive povidone and solvent ethanol, and the mass fraction of the adhesive is 70%; sealing The preparation method of the liquid comprises the following steps: uniformly mixing the adhesive and the solvent to obtain the sealing liquid.

[0033] S3: Combine the capsule body filled with materials and the capsule cap with a liquid film, and then heat the combined capsule in hot air at a temperature of 40°C and a wind speed of 0.5m / s until the solvent in the sealing liquid evaporates completely , the capsule seal is intact.

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Abstract

The invention relates to an internal sealing method and application of a hard capsule. The internal sealing method comprises the following steps: separating a capsule body and a capsule cap of a hard capsule shell and then filling the capsule body with a material; spraying sealing liquid onto the interior surface of the capsule cap so as to form a liquid film; and integrating the capsule body filled with the material and the capsule cap coated with the liquid film and then carrying out heating until the seal of the obtained capsule is intact. The internal sealing method for the hard capsule employs inert gas for carrying the sealing liquid, and when the interior surface of the capsule is coated with the sealing liquid, the material in the capsule is protected by the inert gas, so filling of liquid and materials prone to oxidation into capsules can be realized; and the method does not influence the appearance and sizes of capsules, is extensively applicable to sealing of capsules filled with fat-soluble drugs, and can improve the bioavailability of drugs.

Description

technical field [0001] The invention relates to the technical field of capsule preparation, in particular to a method for sealing the inside of a hard capsule and an application thereof. Background technique [0002] Hard capsules are made by adding a certain amount of medicinal material extracts to powder or excipients to make uniform powder or granules, filling them into hollow capsules, or directly subpacking the medicinal powder into hollow capsules. In the production of modern traditional Chinese medicine preparations, hard capsules have been widely used due to their advantages such as relatively simple process, convenient administration, quick onset of action and ability to effectively isolate the bad smell of medicines. However, the existing hard capsule filling technology cannot achieve complete sealing, so that oxygen-sensitive drugs will be oxidatively degraded when exposed to air for a long time; filling liquid will leak, so it cannot be applied to liquid or Fill...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/42
CPCA61K9/4833A61K47/42
Inventor 胡漳程
Owner 厦门普罗康客科技有限公司