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Medicine for reducing clinical side effects of metaproterenol aerosol

A technology of aerosol and side effects, which is applied in the field of drugs to reduce the clinical side effects of proprofessate aerosol, and can solve problems such as dysuria

Inactive Publication Date: 2017-09-15
沂南县众友中药材种植专业合作社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, aerosol inhalation therapy is one of the main methods for the treatment of chronic bronchitis. Although the effect is better, it often brings side effects such as palpitations, tachycardia, hyperacusis, etc. Blood pressure, tremor, headache, nausea, etc. may also cause side effects of dysuria, which also bring pain to patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0027] Embodiment 1: The drug for reducing the clinical side effects of Probuterol aerosol consists of 14 g of Probuterol, 7 g of biological preparations, 18 g of tetrafluoroethane, 450 g of absolute ethanol, 5 g of Span, and sodium dodecylsulfonate 10g and 4g of apple essence. Grind the biological agent and probutaline through a 200-mesh sieve, add an appropriate amount of purified water and stir to dissolve evenly, then add absolute ethanol, sodium laurylsulfonate, and Span, and stir homogeneously under a high-shear homogenizer for about After 30 minutes, add apple essence, continue to stir for 20 minutes, fill with valves, fill with propellant tetrafluoroethane, check for leaks and weigh, and install a booster. The said disk is disk 85. The biological preparation is prepared by pulverizing and mixing 80 g of Nocturnum foliage, 60 g of Diwupao vine, and 30 g of Aconitum chinensis, adding 8 times the weight of traditional Chinese medicine in distilled water and soaking for 2...

Embodiment approach 2

[0028] Embodiment 2: The drug for reducing the clinical side effects of Probuterol aerosol consists of Probuterol 16g, biological preparation 9g, tetrafluoroethane 20g, absolute ethanol 480g, Span 7g, sodium dodecylsulfonate 15g and 6g of apple essence, the preparation method is the same as that of Embodiment 1.

Embodiment approach 3

[0029] Embodiment 3: The drug for reducing the clinical side effects of Probuterol aerosol consists of Probuterol 18g, biological preparation 11g, tetrafluoroethane 22g, absolute ethanol 500g, Span 9g, sodium dodecylsulfonate 20g and 8g of apple essence, the preparation method is the same as the first embodiment.

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PUM

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Abstract

The invention discloses a medicine for reducing the clinical side effect of probuterol aerosol, which belongs to the technical field of medicines. The aerosol is made of probutene, biological agent, tetrafluoroethane, absolute ethanol, spar, sodium dodecylsulfonate and apple flavor according to certain parts by weight. Clinical trials have proved that the drug effectively overcomes the problem of side effects in the treatment of chronic bronchitis with the commercially available probuterol aerosol.

Description

technical field [0001] The invention belongs to the technical field of medicaments, and in particular relates to a medicine for reducing the clinical side effect of probuterol aerosol. Background technique [0002] Chronic bronchitis is chronic non-specific inflammation of the trachea, bronchial mucosa and surrounding tissues. Clinically, the main symptoms are cough, sputum or wheezing, which lasts for 3 months every year for more than 2 consecutive years. The early symptoms are mild, more than the onset in winter, and relieved in spring and summer. In the late stage, the symptoms can exist all the year round due to the aggravation of inflammation. Its pathological features are bronchial gland hyperplasia and increased mucosal secretion. The disease progresses slowly and is often complicated by obstructive emphysema. In severe cases, pulmonary hypertension and even cor pulmonale often occur. At present, aerosol inhalation therapy is one of the main methods for the treatm...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K36/73A61K9/12A61P11/00
CPCA61K31/137A61K9/0078A61K36/21A61K36/40A61K36/73A61K47/06A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 于名杰
Owner 沂南县众友中药材种植专业合作社
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