Anti-aging composition containing IPS cell extract

An extract and composition technology, applied in the field of medicine, can solve the ethical problems of embryonic stem cells, which cannot be widely used, and the ability of adipose stem cells to proliferate and differentiate.

Inactive Publication Date: 2017-09-15
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the proliferation and differentiation ability of adipose stem cells is far inferior to that of embryonic stem cells, and embryonic stem cells cannot be widely used due to ethical issues

Method used

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  • Anti-aging composition containing IPS cell extract
  • Anti-aging composition containing IPS cell extract
  • Anti-aging composition containing IPS cell extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 A kind of anti-aging tablet comprising IPS cell extract

[0026] The anti-aging tablet containing IPS cell extract is composed of IPS cell extract, grape polyphenols and β-carotene in a mass ratio of 5:2:3.

[0027] The preparation method of the IPS cell extract is divided into the following steps:

[0028] S1. Preparation of feeder layer cells: spread T75 cell culture flask with 2.5mL, 0.5% gelatin and cover the whole bottom, place in 37°C incubator for 45min, add 13mL of cell complete medium pre-incubated at 37°C for 10min, add cell concentration 1.5×10 5 Cells / mL, CF-1 mouse embryonic fibroblasts with a volume of 15mL are cultured, and the feeder layer cells are cultured for the second to three days. When the growth density of the feeder layer cells reaches 80-90%, induced pluripotent stem cells can be inoculated;

[0029] S2. Cultivation of induced pluripotent stem cells: Inoculate the IPS cell suspension obtained from the culture at a volume ratio of...

Embodiment 2

[0034] Embodiment 2 A kind of anti-aging oral liquid comprising IPS cell extract

[0035] The anti-aging oral liquid containing IPS cell extract is composed of IPS cell extract, grape polyphenols and β-carotene in a mass ratio of 5:3:4.

[0036] The preparation method of the IPS cell extract and the extraction method of grape polyphenols are similar to those in Example 1.

[0037] After the IPS cell extract, grape polyphenols and β-carotene are mixed evenly in a mass ratio of 5:3:4, an appropriate amount of medical auxiliary materials is added according to a conventional method to prepare an oral liquid.

Embodiment 3

[0038] Embodiment 3 A kind of anti-aging capsule comprising IPS cell extract

[0039] The anti-aging oral capsule containing IPS cell extract is composed of IPS cell extract, grape polyphenols and β-carotene in a mass ratio of 5:1:2.

[0040] The preparation method of the IPS cell extract and the extraction method of grape polyphenols are similar to those in Example 1.

[0041] The IPS cell extract, grape polyphenols and β-carotene are mixed uniformly according to the mass ratio of 5:1:2, and an appropriate amount of medical auxiliary materials are added according to a conventional method to make capsules.

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PUM

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Abstract

The invention belongs to the field of medicines and particularly relates to an anti-aging composition containing an IPS cell extract. The anti-aging composition comprises the IPS cell extract, grape procyanindin and beta-carotene. The anti-aging composition has an obvious prolonging effect on half survival time, average lifetime and maximum life of fruit flies. The anti-aging composition is capable of significantly strengthening the content of D-galactose-induced sub-aging model SOD and reducing the content of LPO and lipofuscin. The anti-aging composition is significant in anti-aging effect and is safe and nontoxic.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an anti-aging composition containing IPS cell extract. Background technique [0002] Aging is a degenerative change in the functions of various tissues and organs of the body with age, a comprehensive manifestation of various biochemical reactions in the body, and the result of the joint action of many internal and external factors (environmental pollution, mental stress, genetics, etc.). For more than half a century, a series of aging theories have been put forward internationally, laying the foundation for uncovering the mechanism of aging and developing anti-aging drugs. In addition to the above-mentioned representative free radical theory, the mitochondrial DNA damage theory in modern frontier research, and the terminal region theory of aging, there are also cross-linking theory, biofilm damage theory, genetic program theory, chromosomal mutation theory, error theory, immu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61P39/06A61K35/545A61K31/015
CPCA61K31/015A61K35/545A61K36/87A61K2300/00
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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