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A method for measuring reaction kinetics based on single-molecule electrical detection

A technology of reaction kinetics and electrical detection, applied in the direction of material electrochemical variables, etc., can solve the problems of needing labeling and insufficient time resolution

Active Publication Date: 2019-08-30
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the existing problems of single molecular dynamics measurement methods such as the need for labeling and insufficient time resolution, and to provide a method that combines electrical detection with the advantages of non-destructive, label-free, independent of large-scale testing instruments and real-time detection. A method for measuring reaction kinetics based on single-molecule electrical detection

Method used

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  • A method for measuring reaction kinetics based on single-molecule electrical detection
  • A method for measuring reaction kinetics based on single-molecule electrical detection
  • A method for measuring reaction kinetics based on single-molecule electrical detection

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Embodiment Construction

[0033] The present invention will be further described below in conjunction with accompanying drawing.

[0034] see Figure 1-7 , embodiment of the MCBJ device of the present invention Figure 1~3 It includes a base 1 , a stepping motor 2 , piezoelectric ceramics 3 , a suspended incision wire chip 4 , a reaction liquid pool 5 , a fixture 6 , and a sealing cover 7 . exist Figure 4 , including the metal wire 8 .

[0035] Specific examples are given below.

[0036] The kinetic parameters of the D-A reaction process were tested using the MCBJ device.

[0037] 1. Preparation of molecular solution

[0038] Get 0.236mg double-ended pyridyl tetrazine molecules (C 12 h 8 N 6 ) in a solvent bottle, use a 1000 μL pipette gun to take 1000 μL of tetrahydrofuran (THF) solvent and dissolve it in the solvent bottle, close the bottle cap tightly, shake it several times, and ultrasonicate for 5 minutes until the powder is completely dissolved. Take 100 μL of the molecular solution fro...

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Abstract

The invention discloses a reaction kinetics measurement method based on single molecule electrical detection, and involves a chemical reaction kinetics measurement method. The method comprises the following steps: mixing molecular solid and a solvent, and obtaining a molecular solution; placing a chip under a microscope, aligning a blade with a metal wire, firstly conducting cross-cutting, and then cutting the metal wire through a tip of the blade to get the chip; installing the chip, a reaction pool, an O-ring and a seal cover; opening a motor, passing the blade to an incision through the upper top of the motor, and fracturing to form a nano-gap; conducting an in situ test, data record and data analysis, when the metal atoms point contact is disconnected and an electrode is formed; and conducting statistics on the distance between the step and the end in a conductance-distance curve, obtaining a column-like statistical chart, providing another dimension information for an electrical measurement of a molecular junction by the conductance-distance curve, observing changes in conductance in a BJ process when the molecular junction is stretched and closed with the electrode pair, obtaining the interval size opened by the electrode pair, and ultimately inferring the evolution information that the molecular junction conductance changes with the distance.

Description

technical field [0001] The invention relates to a method for measuring chemical reaction kinetics, in particular to a method for measuring reaction kinetics based on single-molecule electrical detection. Background technique [0002] Chemical kinetics is a science that studies reaction rates and reaction mechanisms. It includes traditional macroscopic reaction kinetics and modern molecular reaction kinetics. It is the study of chemical reaction rates and the influence of various factors on reaction rates, and tries to Theoretical calculations of rates are used to predict the kinetics of the entire reaction. The study of reaction kinetics is of great significance to the understanding of the essential mechanism of chemical reactions, the development of reaction processes, and the design of reactors. Molecular reaction dynamics is the frontier basic research field of chemistry. It uses advanced analysis methods of modern physical chemistry, such as laser, ultra-high vacuum, ph...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/48
Inventor 洪文晶黄晓艳刘俊扬张珑漪郑珏婷师佳
Owner XIAMEN UNIV
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