Rotundic acid derivant having effect of preventing and treating tumour metastasis

A technology for anticancer drugs and tumor metastasis, which can be applied in the fields of antineoplastic drugs, medical preparations containing active ingredients, organic chemistry, etc., and can solve the problem of preparing drugs for the prevention and treatment of tumor metastasis from derivatives of anticancer drugs that have not been found. However, there are no reports in the literature on the prevention and treatment of tumor metastasis by the derivatives of basic acid, which can inhibit the ability of movement and migration, improve solubility and good selectivity.
CN107200769AActive Publication Date: 2017-09-26JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JILIN ACAD OF TRADITIONAL CHINESE MEDICINE
Publication Date
2017-09-26

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Abstract

The invention provides application of a rotundic acid derivant in preparation of a medicine for preventing and treating tumour metastasis. An in vitro experiment proves that the rotundic acid derivant disclosed by the invention has significant inhibition effects on proliferation, adhesion, migration and the like of tumor cells, and is safe and low-toxicity to normal cells of a human body. An in vivo animal experiment proves that experimental lung metastasis of B16-F10 melanoma of mice can be effectively reduced, and a preferable tumour metastasis prevention effect is prompted. The rotundic acid derivant disclosed by the invention can be applied to a medicine for preventing the tumour metastasis, so that new application of the rotundic acid derivant to prevention and treatment of tumors is developed, and a new choice is provided for developing a new drug for treating the tumour metastasis and preventing postoperative re-metastasis of malignant tumour; moreover, the rotundic acid derivant has more obvious pharmacological activity.
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Description

Technical field

[0001] The invention relates to a medicine for preventing postoperative metastasis of malignant tumors, in particular to the application of salvage acid derivatives in medicines for preventing and treating tumor metastasis, and belongs to the field of medicine. Background technique

[0002] Malignant tumors are one of the major diseases that seriously endanger human health. Most of the deaths of tumor patients are caused by late metastasis of malignant tumors. Tumor metastasis refers to the process of tumor cells dissociating from the primary tumor, infiltrating into the surrounding tissues, invading into the circulatory system, and then transferring in the body, and adhering to endothelial cells to form metastases. Tumor metastasis is one of the main reasons why tumors are difficult to cure and relapse, and it is also a key factor leading to the death of tumor patients. Clinical diagnosis results show that more than 60% of newly diagnosed tumor patients have met...

Claims

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