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Formulation and its preparation method and application

A preparation and application technology, applied in the field of preparations, can solve the problems of detrimental positive effects for patients and no therapeutic effect for pain

Active Publication Date: 2021-03-02
SANOFI AVENTIS HEALTHCARE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although drugs such as NSAIDs have been shown to be potent and effective in treating pain and inflammation, patients may overuse these drugs and may suffer side effects that detract from their positive effects
There are also concerns that drugs such as NSAIDs merely mask pain and inflammation without any therapeutic effect on the underlying cause of pain

Method used

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  • Formulation and its preparation method and application
  • Formulation and its preparation method and application
  • Formulation and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0100] Introduction

[0101] Rat collagenous arthritis is an experimental model of polyarthritis that has been extensively used in preclinical testing of many antiarthritic agents used in preclinical or clinical research, or It is currently commonly used as a therapeutic agent for this disease (Trentham et al., 1977; Bendele, McComb et al., 1999; Bendele, 2001). This model is characterized by intense, measurable polyarticular inflammation, marked cartilage damage associated with articular pannus formation, and reliable onset and progression of mild to moderate bone resorption and periosteal bone hyperplasia. Therapeutic agents that inhibit the production or activity of interleukin-1 (IL-1) are particularly effective in this test system (Bendele, McAbee et al., 1999), but other types of anti-inflammatory agents are favored for superior activity (cf. Bendele, McComb et al., 1999; Bendele, 2001).

[0102] The current study was conducted by oral (PO) gavage administered twice da...

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PUM

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Abstract

A method comprising one or more omega-3 fatty acids and / or one or more derivatives thereof, willow bark or extract, one or more components thereof and / or derivatives thereof, and withania or extract A formulation of a substance, one or more components thereof and / or derivatives thereof capable of treating or preventing pain, inflammation and / or improving mobility in a subject. A method for treating or preventing one or more diseases, disorders or conditions, such as pain, inflammation and / or poor mobility, comprising administering the formulation to a subject.

Description

technical field [0001] The present invention relates to the treatment of pain and / or inflammation. In particular, the present invention relates to a preparation comprising omega-3 fatty acids, willow bark, and withania, which is particularly effective in treating joint pain and / or inflammation. This formulation can help improve patient mobility. Background technique [0002] Pain is a neuropathic response perceived by a patient in response to stimulation of peripheral nerves ("nociceptive pain"), an inflammatory disease or condition, and / or damage or destruction of elements of the nervous system ("neuropathic pain"). Joint pain is especially problematic due to its chronicity, recurring nature, and severity of pain. This type of pain is usually associated with bone or cartilage damage and / or inflammation to the bony joints or other bony structures. These include pain in the knees, ankles, hips, back, neck, elbows, fingers, wrists and shoulders, which can result from struct...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/202A61K36/76A61K36/81A61P19/02A61P29/00
CPCA61K36/76A61K36/81A61K31/202A61K45/06A61K9/4808A61P19/02A61P29/00A61K2300/00
Inventor A·B·史密斯
Owner SANOFI AVENTIS HEALTHCARE