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Externally-used cream composition containing fusidic acid

A technology of fusidic acid and cream for external use, which is applied in the field of medicine, and can solve the problems of not paying attention to the degradation of impurities, difficulty in preparing water-soluble preparations, and poor water solubility of sidic acid.

Inactive Publication Date: 2017-10-03
天津双硕医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] After searching, it was found that the current preparation research, especially in the research of external preparations, did not pay attention to the degradation of impurities in these two aspects at the same time, so as to obtain stable fusidic acid external preparations.
[0012] In addition, due to the poor water solubility of fusidic acid, it is difficult to prepare water-soluble preparations, such as sprays, solutions, etc.

Method used

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  • Externally-used cream composition containing fusidic acid
  • Externally-used cream composition containing fusidic acid
  • Externally-used cream composition containing fusidic acid

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0083] Embodiment 1 Fusidic acid cream preparation (unit: g)

[0084] prescription:

[0085]

[0086] Preparation Process:

[0087] Step 1: Superfinely pulverize the fusidic acid raw material so that the average particle size is less than 20 μm, and set aside;

[0088] Step 2: Take propylene glycol as the oil phase solvent and heat it in a water bath to 60°C under the condition of nitrogen protection, then take the prescribed amount of antioxidant butyl hydroxyanisole, fusidic acid, thickener cetyl alcohol, and emulsifier monohard Fatty acid glyceride, stirred, dissolved, is the oil phase;

[0089] Step 3: Take purified water, heat it in a water bath to 60°C, add acetic acid and emulsifier polysorbate 80, stir to dissolve, adjust the pH value to 4.0-5.5 with NaOH aqueous solution, and form acetic acid-sodium acetate buffer pair in the solution to form water Mutually;

[0090] Step 4: Add the water phase to the oil phase in a vacuum state, lower the temperature, and cont...

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Abstract

Aiming at the defects that a fusidic acid preparation is easy to oxidatively degrade and hydrolyze, an inventor proposes to avoid oxidation and hydrolysis reaction by a mode of adding an antioxidant into a preparation system and hydrolyzing a stabilizer; the problem of dissolution of fusidic acid is successfully solved by selecting particle sizes of crude drugs and dissolving, the fusidic acid can exist in cream in a molecular state, and stability and curative effect of a cream preparation are improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an external cream composition containing fusidic acid, a preparation method and application thereof. Background technique [0002] The widespread resistance of Staphylococcus to a variety of antimicrobial drugs has made clinical treatment difficult. The isolation rate of methicillin-resistant Staphylococcus varies greatly across the world, but all show a rapid upward trend. The results of bacterial drug resistance surveillance in my country show that the proportion of methicillin-resistant staphylococci isolated from clinical trials mostly accounts for more than 50% of staphylococci. So far, only vancomycin and teicoplanin have been used in the clinical treatment of methicillin-resistant staphylococcus infections in my country. Long-term and frequent use will inevitably lead to the occurrence of bacterial resistance; for this reason, new antibacterial drugs should be...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/10A61K47/12A61K47/26A61K47/14A61K31/56A61P31/04
CPCA61K9/06A61K9/0014A61K31/56A61K47/10A61K47/12A61K47/14A61K47/26
Inventor 不公告发明人
Owner 天津双硕医药科技有限公司
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