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A kind of preparation method of highly air-permeable burn and scald dressing

A gas-permeable, burn-and-scald technology, applied in bandages, medical science, etc., can solve problems such as low adhesion and no ability to promote wound healing, and achieve high moisture retention, optimized pore-forming effect, and high porosity

Active Publication Date: 2020-04-28
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(4) Low adhesion
Wound healing is a complex process, but general dressings do not have the effect of promoting wound healing
At present, there are a large number of various burn and scald dressings on the market, such as animal collagen, chitosan, and hyaluronic acid, which are commonly used raw materials for burn and scald dressings. However, the prepared burn and scald dressings are difficult to perfectly solve the above problems

Method used

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  • A kind of preparation method of highly air-permeable burn and scald dressing
  • A kind of preparation method of highly air-permeable burn and scald dressing
  • A kind of preparation method of highly air-permeable burn and scald dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of dressing for burns and scalds

[0024] Step 1: Dissolve water-soluble protein HLC in 10 mL distilled water to obtain an HLC solution with a concentration of 200 mg / mL, and add 2% cross-linking agent β-diimine zinc complex and 1, 2, 7, 8 - Diepoxyoctane each 2 mL, then add 2 mL of 10 mg / mL KCl solution, mix well, and adjust the pH of the solution to 4.5 with dilute hydrochloric acid;

[0025] Step 2: Divide the mixed solution in step 1 into molds, keep at 50°C for 2 hours, then transfer to a high-pressure steam sterilizer and keep at 121°C for 20 minutes to obtain the primary gel product;

[0026] Step 3: soak and wash the primary gel in step 2 with distilled water for 5 days, and change the washing water every 6 hours to remove salt and residual crosslinking agent; transfer the washed primary gel to a high-pressure steam sterilizer Continue to keep at 121°C for 2 h, then soak and wash with distilled water again for 2 days, control the total amo...

Embodiment 2

[0032] Example 2 Preparation of dressing for burns and scalds

[0033]Step 1: Dissolve the water-soluble protein BSA in 10 mL distilled water to obtain a BSA solution with a concentration of 100 mg / mL, and add 2% cross-linking agent β-diimine zinc complex and 1, 2, 7, 8 - Diepoxyoctane 1 mL each, then add 2 mL of 10 mg / mL NaCl solution, mix well, and adjust the pH of the solution to 3.5 with dilute hydrochloric acid;

[0034] Step 2: Divide the mixed solution in step 1 into molds, keep at 60°C for 2 hours, then transfer to a high-pressure steam sterilizer and keep at 121°C for 20 minutes to obtain the primary gel product;

[0035] Step 3: soak and wash the primary gel in step 2 with distilled water for 5 days, change the washing water every 6 hours to remove salt and residual cross-linking agent; transfer the washed primary gel to an autoclave to continue Keep at 121°C for 2 h, then soak and wash with distilled water for 2 days again, control the total amount of residual cros...

Embodiment 3

[0038] Example 3 Preparation of dressing for burns and scalds

[0039] Step 1: Dissolve α-lactalbumin in 10 mL distilled water to obtain a solution with a concentration of 100 mg / mL, add 1% cross-linking agent β-diimine zinc complex and 1, 2, 7, 8 - Diepoxyoctane each 2 mL, then add 50 mg / mL NaNO 3 Solution 2mL, mix well, and adjust the pH of the solution to 5.5 with dilute hydrochloric acid;

[0040] Step 2: Divide the mixed solution in step 1 into molds, keep at 50°C for 2 hours, then transfer to a high-pressure steam sterilizer and keep at 121°C for 20 minutes to obtain the primary gel product;

[0041] Step 3: soak and wash the primary gel in step 2 with distilled water for 5 days, change the washing water every 6 hours to remove salt and residual cross-linking agent; transfer the washed primary gel to an autoclave to continue Keep at 121°C for 2 h, then soak and wash with distilled water for 2 days again, control the total amount of residual cross-linking agent to be le...

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Abstract

The invention discloses a method for preparing a medical burn and scald dressing. Specifically, the water-soluble macromolecular protein is dissolved in ultrapure water, the pH of the solution is adjusted to 2-5.5, and then inorganic salts and cross-linking agent β-dioxide are added. Amine-zinc complex and 1,2,7,8-diepoxyoctane were stirred evenly and then heated in a water bath for reaction and high-temperature treatment to obtain the initial superporous hydrogel. After washing with water and soaking in antibiotic solution, it was freeze-dried and Co-60 After irradiation and sterilization, a new type of highly breathable burn and scald dressing is obtained. The burn and scald dressing has high air permeability, high water absorption and high moisturizing properties, and can absorb excess exudate from the wound while ensuring that the water in the wound does not evaporate excessively. The dressing prepared by the invention does not adhere to the wound, thereby avoiding the wound Pain caused to the patient during the recovery process.

Description

technical field [0001] The invention relates to a preparation method of a highly air-permeable burn and scald dressing, which belongs to the technical field of medical materials. Background technique [0002] Medical wound dressings usually have the following requirements: (1) Physical barriers. One of the main functions of medical dressings is to prevent wound exudate from polluting other parts of the body. As a physical barrier, dressings can effectively isolate the wound from the air when used on the wound, thereby preventing bacteria and dust particles from entering the wound. (2) The dressing is non-toxic. This requires that the raw materials for preparing the dressing are non-toxic or that the residual amount of toxic substances in the finished dressing meets the national safety standards. (3) It can maintain the moist environment of the wound surface and has a certain degree of ventilation. (4) Low adhesion. For patients with large area injuries, if the dressing a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08J3/075C08J3/24C08J9/40
CPCA61L26/0028A61L26/0033A61L26/0047A61L26/0066A61L26/0085A61L2300/216A61L2300/406C08J3/075C08J3/24C08J9/40C08J2207/12C08J2389/00
Inventor 范代娣惠俊峰邓建军段志广李伟娜姜西娟
Owner NORTHWEST UNIV
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