Anti MUC1 CAR-T cell and its preparation method and application

A technology of cells and lymphocytes, applied in the field of gene-modified cells and tumor treatment, to achieve the effect of high-efficiency tumor-killing activity
CN107227299BActive Publication Date: 2020-11-24刘未斌
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
刘未斌
Publication Date
2020-11-24

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Abstract

The invention provides an Anti-MUC1 CAR-T cell and its preparation method and application. The Anti-MUC1 CAR-T cell expresses a SCFV-IgD-CD28-OX40-CD3 zeta fusion protein in the T cell. In the SCFV-IgD-CD28-OX40-CD3 zeta fusion protein, the SCFV is used to bind to the MUC1 protein. The amino acid sequence of SCFV is a first sequence. The cell is obtained by ornament and modification of the T cell, can specifically recognize and kill adenocarcinoma and is suitable for prevention and treatment on the corresponding tumor diseases.
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Description

technical field

[0001] The invention relates to an Anti MUC1 CAR-T cell and its preparation method and application, belonging to the technical field of gene modified cells and tumor treatment. Background technique

[0002] In tumor immunotherapy methods, lymphocyte immune technology, including cytokine-induced killer cells, cytotoxic T lymphocytes and infiltrating T lymphocytes, has been used in clinical treatment of malignant tumors at home and abroad, and has achieved some clinical curative effects, but it is not Non-specific immune effect, due to the immune escape of tumor cells themselves and the concealment of antigens, it is still very limited in eliminating tumor cells in vivo. The emergence of chimeric antigen receptor genetically modified lymphocyte technology provides a new direction for clinical treatment of cancer. Chimeric antigen receptor T cell (Chimeric antigen receptor T cell, referred to as: CAR-T cell) therapy is to extract T lymphocytes from patients, un...

Claims

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