Preparation method of nano-divalent silver-supported silica gel antiseptic dressing

A nano-oxidation and silica gel technology, applied in medical science, bandages, etc., can solve the problems of discounted bactericidal effect, easy dissociation of silver ions, etc., and achieve the effect of high silver loading, efficient bactericidal effect, and excellent stability

Inactive Publication Date: 2017-10-10
苏州聚容纳米科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the adsorbed silver ions are easy to dissociate, which greatly reduces the bactericidal effect

Method used

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  • Preparation method of nano-divalent silver-supported silica gel antiseptic dressing
  • Preparation method of nano-divalent silver-supported silica gel antiseptic dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Embodiment 1, a preparation method of a nano-silver oxide-loaded silicone gel antibacterial dressing, comprising the following steps: weighing 945 parts of deionized water, 8 parts of sodium hydroxide, 12 parts of potassium persulfate, and 5 parts of polyvinylpyrrolidone (K30, the average molecular weight is 50,000), 5 parts of polyvinyl alcohol (molecular weight 50,000), put into the reaction kettle, control the temperature to 65 ℃, stir and dissolve, and record it as liquid A; weigh 5 parts of silver nitrate and 5 parts of potassium persulfate , dissolved in 20 parts of water, and recorded as liquid B; use a peristaltic pump to add liquid B to liquid A at a rate of 0.1 ml / min, and continue to stir at constant temperature for 4 hours after the injection is completed to complete the reaction; filter the obtained reaction suspension , the filtrate was washed with deionized water until neutral, and then dried under vacuum for use, and the obtained product was nano-silver o...

Embodiment 2

[0029] Embodiment 2, a preparation method of a nano-silver oxide-loaded silicone gel antibacterial dressing, comprising the following steps: weighing 950 parts of deionized water, 8 parts of sodium hydroxide, 12 parts of potassium persulfate, and 4 parts of polyvinylpyrrolidone (K25, the average molecular weight is 30000), 2 parts of polyvinyl alcohol (molecular weight 80000), added to the reaction kettle, the temperature is controlled to 80 ° C, stirred and dissolved, recorded as A solution; Weigh 3 parts of silver nitrate and 3 parts of potassium persulfate , dissolved in 20 parts of water, and recorded as liquid B; use a peristaltic pump to add liquid B into liquid A at a rate of 0.2 ml / min, and continue to stir at constant temperature for 4 hours after the injection is completed to complete the reaction; filter the obtained reaction suspension , the filtrate was washed with deionized water until neutral, and then dried under vacuum for use, and the obtained product was nano...

Embodiment 3

[0030]Embodiment 3, a preparation method of a silicone gel antibacterial dressing loaded with nano-silver oxide, comprising the following steps: weighing 955 parts of deionized water, 8 parts of sodium hydroxide, 12 parts of potassium persulfate, and 2 parts of polyvinylpyrrolidone (K25, average molecular weight 30000), 1 part of polyvinyl alcohol (molecular weight 100000), add to the reaction kettle, control the temperature at 90 ℃, stir and dissolve, record as liquid A; weigh 2.5 parts of silver nitrate and 2.5 parts of potassium persulfate , dissolved in 20 parts of water, and recorded as liquid B; use a peristaltic pump to add liquid B to liquid A at a rate of 0.3ml / min, and continue to stir at a constant temperature for 4 hours after the injection is completed to end the reaction; filter the obtained reaction suspension , the filtrate was washed with deionized water to neutrality, and then vacuum-dried and dried for use, and the obtained product was nano-silver oxide. In ...

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Abstract

The invention discloses a preparation method of a nano-divalent silver-supported silica gel antiseptic dressing. The preparation method comprises the following steps: (1) weighing 85-96 parts of deionized water, adding 1-5 parts of a hydrogen peroxide solution with the concentration of 30%, adding 0.01-0.05 part of nano-divalent silver, and conducting marking as a C solution; (2) regulating the C solution with a nitric acid water solution until the hydrogen ion exponent pH value of the C solution is 2-5, and conducting marking as a D solution; (3) adding 3-5 parts of organic silicon to the D solution, conducting hydrolysis for 2 hours, and conducting marking as an E solution; and (4) regulating the E solution with sodium hydroxide until the pH value is 6-7, then adding 1-2 parts of glycerol, and finally conducting standing and aging for 48 hours for gel formation. Through the above mode, the preparation method of the nano-divalent silver-supported silica gel antiseptic dressing integrates the excellent stability of silica gel and the high-efficiency sterilizing effect of nano-divalent silver, is high in the amount of supported silver and very stable, has long-term sterilization and antibacterial effects, can be mass produced and is nontoxic and harmless.

Description

technical field [0001] The invention relates to the technical field of antibacterial dressings, in particular to a preparation method of a nanometer high silver oxide-loaded silicon gel antibacterial dressing. Background technique [0002] In modern life, with the continuous maturity of nanomaterial preparation technology and people's higher and higher requirements for life hygiene, people have a huge demand for various antibacterial products. As early as 1994, it was found that the antibacterial properties of nano-silver are much inferior to that of monovalent silver ions Ag+, especially the high-valent silver ions Ag2+; Ag2+ has a high redox potential (Ag2+ potential is 2.00eV, Ag+ potential is 0.7991. eV, 25℃) makes Ag2+ more than 200 times more effective than Ag+. Nano-silver oxide has the advantages of strong antibacterial, sterilization, disinfection, no side effects, good stability, long-lasting antibacterial, no drug resistance, safety and environmental protection. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0014A61L26/0066A61L26/008A61L2300/104A61L2300/404A61L2300/602C08L39/06C08L29/04
Inventor 程志峰吴勇飞张艳
Owner 苏州聚容纳米科技有限公司
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