Compound flunixin meglumine injection and preparation method thereof

A technology of compound flunixin meglumine and flunixin meglumine, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of antibiotic residue treatment time and other issues

Inactive Publication Date: 2017-10-20
吉林省力畜达动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a compound flunixin meglumine injection and a preparation method thereof in order to solve the technical problems that existing flunixin meglumine compound preparations have antibiotic residues and long treatment time

Method used

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  • Compound flunixin meglumine injection and preparation method thereof
  • Compound flunixin meglumine injection and preparation method thereof
  • Compound flunixin meglumine injection and preparation method thereof

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preparation example Construction

[0035] The present invention also provides a preparation method of compound flunixin meglumine injection, the method comprising:

[0036] Take water for injection, add polyethylene glycol and propylene glycol, heat to 50-60°C, add flunixin meglumine, stir to dissolve, then add thymosin or transfer factor, mix well, adjust the pH value to 7.8-9.0, water for injection Add to full amount, mix evenly, filter, pot, sterilize, and package to obtain compound flunixin meglumine injection.

Embodiment 1

[0039] A kind of compound flunixin meglumine injection, its prescription is composed of by weight: flunixin meglumine 8.4%, macrogol 400 33.5%, propylene glycol 10.4%, thymosin 0.05%, ethanolamine to adjust the pH value 7.8~9.0.

[0040] Preparation method and steps: Take 300ml of water for injection, 335g of polyethylene glycol (400), 104g of propylene glycol, heat to 50°C, add 84g of flunixin meglumine, stir to dissolve, add calf thymosin (calculated as polypeptide) 0.5 g, mix evenly, add ethanolamine to adjust the pH to 7.8-9.0, add water for injection to 1000ml, mix evenly, filter, pot, sterilize, and pack.

Embodiment 2

[0042] A compound flunixin meglumine injection, its prescription consists of (by weight): flunixin meglumine 8.4%, polyethylene glycol 400 33.5%, propylene glycol 10.4%, thymosin 0.5%, ethanolamine to regulate pH The value is 7.8 to 9.0.

[0043] Preparation method and steps: Take 300ml of water for injection, 335g of polyethylene glycol (400), 104g of propylene glycol, heat to 60°C, add 84g of flunixin meglumine, stir to dissolve, add calf thymosin (calculated as polypeptide) 5.0 g, mix evenly, add ethanolamine to adjust the pH to 7.8-9.0, add water for injection to 1000ml, mix evenly, filter, pot, sterilize, and pack.

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Abstract

The invention provides a compound flunixin meglumine injection and a preparation method thereof, which belong to the technical field of a preparation for veterinary use. The compound flunixin meglumine injection solves the technical problems of antibiotic residues and long treatment time in the current flunixin meglumine compound preparations. Every 1000 mL of the injection contains 50-100 g of flunixin meglumine, 0.5-5.0 g of thymulin (metered by polypeptide) or transfer factors (metered by polypeptide), 100-500 g of polyethylene glycol, 100-500 g of propylene glycol, and the balance of injection water. The invention also provides the preparation method of the compound flunixin meglumine injection. The injection has efficient functions for relieving fever and alleviating pain, and increasing the body immunity, at the same time, the bacteria drug resistance and antibiotic residues cannot be generated during a disease treatment process by the injection; the recovery rate is increased, the treatment cost is reduced, and the culture risk is reduced.

Description

technical field [0001] The invention belongs to the technical field of veterinary preparations, and in particular relates to a compound flunixin meglumine injection and a preparation method thereof. Background technique [0002] In recent years, with the improvement of people's living standards, my country's animal husbandry industry has developed rapidly and has gradually become large-scale and intensive. However, livestock and poultry diseases and infectious diseases have also shown a trend of rapid increase, seriously affecting the health of livestock and poultry and the safety of livestock products. , in the prevention and treatment of diseases, the use of large doses of antibiotics and the addition of a large amount of antibiotics to feed lead to the phenomenon of indiscriminate use of antibiotics, resulting in an increase in the incidence of livestock and poultry diseases, an increase in bacterial resistance, and an increase in the difficulty of treatment, and even There...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K38/22A61K38/19A61K31/44A61P29/00A61P37/04A61P31/04A61P31/12A61P15/00
CPCA61K38/19A61K38/2292A61K47/10A61K9/0019A61K9/08A61K31/44A61K2300/00
Inventor 李忠敬刘青剑韩子愈
Owner 吉林省力畜达动物药业有限公司
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