Aromatic heterocyclic alcohol ring palladium metal catalyst and its application

Abstract

The invention provides an aromatic heterocycte cyclitol palladium metal catalyst. The catalyst is a compound or a corresponding compound salt of a structure shown by a formula (1) or a formula (2). In the formula, n is 1 or 2, R1, R2 and R3 are independent hydrogen (H), methyl (CH3), propyl (C3H7), n-butyl (n-C4H9), n-hexyl (n-C6H13), cyclohexyl, adamantyl, camphoryl, Ph, p-OCH3-Ph, p-F-Ph or fluorenyl. The invention further provides application of the aromatic heterocycte cyclitol palladium metal catalyst in aromatic ring cyanation reaction, aromatic heterocycte C-H activation and arylation reaction, aromatic heterocycte oxidization and dehydrogenation Heck reaction and Suzuki coupling reaction. The formulas are shown in the specification.

Description

technical field [0001] The invention belongs to the field of organometallic chemistry, and specifically relates to an aromatic heterocyclic alcohol ring palladium metal catalyst and its application, more specifically to the synthesis and application of a ring palladium metal catalyst with pyridine or quinoline heterocyclic alcohol as a ligand. Background technique [0002] As we all know, ordinary metal palladium salt catalysts are widely used not only in organic synthesis but also in industry because of their low cost and high efficiency. However, this type of catalyst usually has problems such as large dosage, harsh reaction conditions, and many side reactions, and most of them need to introduce expensive ligands, which not only increases the conversion cost but also causes environmental pollution. In contrast, organic cyclopalladium-based catalysts have the advantages of mild reaction conditions, high catalytic activity and selectivity, and most of them do not require ext...

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Problems solved by technology

[0022] An object of the present invention is to overcome the defects of complex synthetic routes and poor universality in the synthesis of some compounds in the prior art, further expand and enrich the types of palladium catalysts, and provide a new palladium metal catalyst for aromatic heterocyclic alcohols. Aromatic heterocyclic alcohol ring palladium metal catalysts can be used for Suzuki coupling reaction, oxidative dehydrogenation Heck reaction of aromatic heterocyclic rings, cyanation reaction of halogenated (hetero) aromatic hydrocarbons and C-H activated arylation reactions of various aromatic heterocyclic rings catalytic

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