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Technology of preparing mangiferin by using mangifera indica leaves

A technology of mango leaves and mangiferin, which is applied in the field of mangiferin preparation, can solve the problems of reducing product safety, failing to meet the requirements of qualitative and quantitative reference substances, low purity of mangiferin, etc., and achieve the effect of improving safety

Inactive Publication Date: 2017-10-20
广西高企科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides a process for preparing mangiferin from mango leaves to solve the problem that the purity of mangiferin produced in the prior art is low, does not meet the requirements of qualitative and quantitative reference substances, and the use of macroporous resin increases the introduction of The risk of organic residual solvents such as benzene, toluene, xylene, styrene, alkanes, and diethylbenzene, which reduces the safety of products

Method used

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  • Technology of preparing mangiferin by using mangifera indica leaves
  • Technology of preparing mangiferin by using mangifera indica leaves

Examples

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Effect test

Embodiment 1

[0037] A kind of technology that adopts mango leaf to prepare mangiferin, comprises the following steps:

[0038] S1: drying the mango leaves to a moisture content of 3%, crushing and passing through a 70-mesh sieve to obtain mango leaf powder;

[0039] S2: Add 80% ethanol and 1-allyl-3-methylimidazole chloride in a mass ratio of 10:1 to the mango leaf powder prepared in step S1, wherein the mango leaf powder is mixed with ethanol and 1-propyl- The total weight ratio of 3-methylimidazole acetate is 1:6, reflux extraction under water bath conditions twice, each extraction time is 2.2h, after the extraction is complete, combine the extracts, adjust the pH value of the extracts to 5, Control the temperature at 72°C, decolorize and remove impurities by activated carbon for 0.8h, and obtain a decolorizing solution after filtration;

[0040] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved in water at 4...

Embodiment 2

[0046] A kind of technology that adopts mango leaf to prepare mangiferin, comprises the following steps:

[0047] S1: drying the mango leaves to a moisture content of 2.5%, crushing and passing through a 50-mesh sieve to obtain mango leaf powder;

[0048] S2: Adding 75% ethanol and 1-allyl-3-methylimidazole chloride with a mass ratio of 8:1 to the mango leaf powder prepared in step S1, wherein the mango leaf powder is mixed with ethanol and 1-propyl- The total weight ratio of 3-methylimidazole acetate is 1:4, reflux extraction under water bath conditions twice, each extraction time is 2.4h, after the extraction is complete, combine the extracts, adjust the pH value of the extracts to 4.8, Control the temperature at 70°C, decolorize and remove impurities by activated carbon for 1 hour, and obtain a decolorizing solution after filtration;

[0049] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved in wa...

Embodiment 3

[0055] A kind of technology that adopts mango leaf to prepare mangiferin, comprises the following steps:

[0056] S1: drying the mango leaves to a moisture content of 2.2%, crushing and passing through an 80-mesh sieve to obtain mango leaf powder;

[0057] S2: Adding 85% ethanol and 1-allyl-3-methylimidazole chloride with a mass ratio of 12:1 to the mango leaf powder prepared in step S1, wherein the mango leaf powder is mixed with ethanol and 1-propyl- The total weight ratio of 3-methylimidazole acetate is 1:8, reflux extraction 3 times under water bath conditions, each extraction time is 1.8h, after the extraction is complete, combine the extracts, adjust the pH value of the extracts to 5.1, Control the temperature at 75°C, decolorize and remove impurities by activated carbon for 0.5h, and obtain a decolorizing solution after filtration;

[0058] S3: Concentrate and dry the primary decolorization solution obtained in step S2 to obtain an extract extract, which is dissolved i...

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Abstract

The invention discloses a technology of preparing mangiferin by using mangifera indica leaves, and belongs to the technical field of mangiferin preparation. The mangiferin is prepared by the following steps: performing crushing; performing first decoloration; performing crystallization; performing second decoloration; performing recrystallization; performing extraction, separation and purification; performing concentration and crystallization; and performing drying. The mangiferin prepared by the technology provided by the invention has purity of 99.09% or above, which is higher than the purity of mangiferin prepared by prior arts, and the purity of the mangiferin prepared by the technology provided by the invention reaches the requirement of a qualitative or quantitative reference substance. The technology provided by the invention avoids using a macroporous resin, reduces the risk of introducing residual organic solvents of benzene, methylbenzene, xylene, styrene, alkanes and diethylbenzene, and improves the safety of products.

Description

【Technical field】 [0001] The technical field of mangiferin preparation of the present invention particularly relates to a process for preparing mangiferin from mango leaves. 【Background technique】 [0002] Mango, an evergreen tree, originated in India, and is now planted in tropical regions. It is cultivated in southern China, in villages or houses in Guangxi, Guangdong, and Hainan. Scattered plants can be seen in slightly moistened soil. Mango leaf is the leaf of Mango Mangiferaindica L, a plant of Anacardiaceae. It is a local traditional Chinese medicine in Guangxi. It is recorded in "Guangxi Traditional Chinese Medicinal Materials Standard" 1990 edition. Mangiferin is the main activity of mango leaf to relieve cough, reduce phlegm and anti-inflammatory Components, mangiferin has anti-inflammatory, anti-virus, central nervous system suppression and immunosuppressive effects, as well as anti-lipid peroxidation and anti-tumor effects. It is commonly used to treat hepatitis. ...

Claims

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Application Information

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IPC IPC(8): C07H17/04C07H1/08
CPCC07H1/08C07H17/04Y02P20/54
Inventor 石东秀
Owner 广西高企科技有限公司
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