Preparation method and application of antibacterial silicone rubber

A technology of silicone rubber and reaction, which is applied in the field of preparation of antibacterial silicone rubber, can solve the problems of poor drug resistance and biocompatibility, and achieve good biocompatibility and good stability

Active Publication Date: 2017-10-24
泰州度博迈医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial silicone rubber prepared by this method solves the problems of easy drug resistance and poor biocompatibility of the existing antibacterial silicone rubber, and has a good application prospect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A preparation method of antibacterial silicone rubber, comprising the steps of:

[0037] S1. Immerse the silicone rubber in a toluene solution containing 0.1% γ-aminopropyltriethoxysilane, the volume ratio of the surface area of ​​the silicone rubber to the toluene solution containing 0.1% γ-aminopropyltriethoxysilane is 1cm 2 : 100mL, shake and react at 20°C for 12 hours; take out the silicone rubber, wash it with absolute ethanol, and dry it to obtain a silicone rubber with amino groups on the surface;

[0038] S2. Immerse the silicone rubber containing amino groups on the surface into a N,N-dimethylformamide solution containing 0.1 wt% N(ε)-benzyloxycarbonyl-L-lysine-N-carboxylic acid anhydride in dewatered form, The volume ratio of the surface area of ​​silicone rubber to the N,N-dimethylformamide solution containing N(ε)-benzyloxycarbonyl-L-lysine-N-carboxylic acid anhydride is 1cm 2 : 100mL, feed into dehydrated argon, initiate polymerization at 0°C, react for 12...

Embodiment 2

[0044] A preparation method of antibacterial silicone rubber, comprising the steps of:

[0045] S1. Immerse the silicone rubber in a chloroform solution containing 5% γ-aminopropylmethyldiethoxysilane, the volume ratio of the surface area of ​​the silicone rubber to the chloroform solution containing γ-aminopropylmethyldiethoxysilane 1cm 2 : 10mL, shake and react at 20°C for 12 hours; take out the silicone rubber, wash it with absolute ethanol, and dry it to obtain a silicone rubber with amino groups on the surface;

[0046] S2, immerse the silicone rubber containing amino group on the surface into the N,N-dimethylacetamide solution containing 20wt% L-histidine-N-carboxylic acid anhydride and L-leucine-N-carboxylic acid anhydride , the volume ratio of the surface area of ​​silicone rubber to the N,N-dimethylacetamide solution containing L-histidine-N-carboxylic anhydride and L-leucine-N-carboxylic anhydride is 1cm 2 : 10mL, the molar ratio of L-histidine-N-carboxylic acid an...

Embodiment 3

[0051] A preparation method of antibacterial silicone rubber, comprising the steps of:

[0052] S1. Immerse the silicone rubber into a xylene solution containing 50% γ-aminopropyltrimethoxysilane, the volume ratio of the surface area of ​​the silicone rubber to the xylene solution of γ-aminopropyltriethoxysilane is 1cm 2 : 0.01mL, shake and react at 50°C for 0.5 hours; take out the silicone rubber, wash it with absolute ethanol, and dry it to obtain a silicone rubber with amino groups on the surface;

[0053] S2, immerse the silicone rubber containing amino group on the surface into the tetrahydrofuran solution containing 60wt% N'-benzyloxycarbonyl-L-ornithine-N-carboxylic acid anhydride of dewatering, the surface area of ​​silicone rubber is the same as that containing N'-benzyloxycarbonyl -The volume ratio of the tetrahydrofuran solution of L-ornithine-N-carboxylic acid anhydride is 1cm 2 : 0.1mL, pass into dehydrated argon, initiate polymerization at 30°C, and react for 12...

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PUM

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Abstract

The invention discloses a preparation method of antibacterial silicone rubber. The preparation method comprises the following step: inducing ring opening polymerization of amino acid N-carboxylic acid anhydride in situ by virtue of amino on the surface of silicone rubber, so as to obtain the silicone rubber with the surface containing a polyamino acid copolymer or a polyamino acid homopolymer. According to the antibacterial silicone rubber prepared by virtue of the preparation method, the problems that existing antibacterial silicone rubber easily generates drug resistance and is poor in biocompatibility are solved, and the antibacterial silicone rubber has good application prospects. The antibacterial rate of the prepared antibacterial silicone rubber to bacteria including escherichia coli, staphylococcus aureus, staphylococcus epidermidis, pseudomonas aeruginosa, Candida albicans, pneumococcus and the like exceeds 90%, and the cytotoxicity of mouse fibroblast does not exceed level 1.

Description

technical field [0001] The invention relates to a preparation method and application of silicone rubber, in particular to a preparation method and application of antibacterial silicone rubber. Background technique [0002] Silicone rubber has excellent biological safety and chemical inertness. It is an excellent medical material and has been widely used in catheters, drainage tubes, breathing catheters, cervical occluders, wound dressings and other fields. However, silicone rubber needs to be in contact with human tissues such as the urethra and skin for a long time during use. As an exogenous artificial material, the surface of silicone rubber is prone to bacterial adhesion and proliferation, and even forms a biofilm on its surface, and with time As the residence time of silicone rubber increases, the probability of bacterial infection increases. As a "protective umbrella" for microorganisms, biofilms can resist the impact of antibiotics on microorganisms, and even enter t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/42C08G77/388A61L29/06A61L29/16A61L31/16A61L31/06A61L15/46A61L15/26A61L26/00A61K8/88A61Q17/00
Inventor 牛之猛张善勇
Owner 泰州度博迈医疗器械有限公司
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