A method for purification and preparation of a dolantin standard substance used for courtroom scientific drug detection

Abstract

A method for purification and preparation of a dolantin standard substance used for courtroom scientific drug detection is disclosed. The method includes (1) detecting purity of dolantin in a captured dolantin sample, with the captured dolantin sample the dolantin mass percentage of which is greater than or equal to 70 wt% being adopted as a raw material for purification and preparation of the dolantin standard substance; and (2) preparing the dolantin standard substance by utilizing high performance liquid chromatography. The dolantin obtained by the method is confirmed by nuclear magnetic resonance, liquid chromatogram-tandem mass spectrometry and infrared spectroscopic analysis, the purity value of the dolantin obtained by the method is determined by liquid chromatography and gas chromatography, and impurities unresponsive to chromatography are measured. According to requirements on standard substance preparation, stability, uniformity, a definite value, and total uncertainty estimation of the prepared standard substance meet related regulations and reach expected indexes.

Description

technical field [0001] The invention relates to the preparation of forensic science drug standard products. More specifically, it relates to a method for purifying and preparing pethidine standard substances used in forensic drug detection. Background technique [0002] At present, the increasingly serious drug problem has become a global disaster. The proliferation of drugs directly endangers people's physical and mental health, and poses a huge threat to economic development and social progress. Therefore, establishing a forensic scientific drug detection quantity traceability system, improving the measurement technology of drug components, ensuring the reliability and comparability of measurement results, establishing the sharing and mutual recognition of measurement data, and providing accurate and reliable evidence for courts has become a national standard in the world. A general concern of drug identification agencies. [0003] Drug composition measurement technolog...

AI Technical Summary

Problems solved by technology

All of these bring certain uncertainties to the detection of drug-related cases, which directly affect the accuracy of quantitative results.

Moreover, the lack of domestic drug standard substances has become a major obstacle restricting my country from realizing the standardization of forensic scientific drug detection chemical measurement methods, traceability and mutual recognition of measurement results.

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