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Method for promoting hair growth

A technology for hair growth and hair follicles, applied in the field of beauty and health care, can solve problems such as affecting hair growth, slow growth, and falling off, and achieve the effects of less toxic and side effects, easy absorption, and simple operation.

Inactive Publication Date: 2017-11-24
SHENZHEN TIANYUAN STEM CELL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, due to a variety of reasons, in people's daily life and work, some abnormalities will occur in human hair growth, such as slow growth or even loss, or hair growth is affected by skin injuries. How to use known technology to restore some abnormal hairs to normal Hair growth, or making some injured skin grow hair, is an important subject of research and struggle for relevant technical personnel in the current scientific and technological circles, and it is also an urgent desire of some people with abnormal hair

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The specific process of Bpv (phen) promoting mouse telogen hair follicles to enter the growth phase is as follows:

[0023] 1. Anesthetize 7-9 week old mice with sodium pentobarbital;

[0024] 2. Use depilatory cream to remove the hair on the back of the mouse;

[0025] 3. Dissolve 0.2mg of bpv (phen) inhibitor and 10mg of PLGA / TPGS nanomaterials in 5ml of acetone, stir and centrifuge, resuspend with 50ul PBS, PLGA / TPGS / PBS as a control, and then subcutaneously injected into the back of the mouse;

[0026] 4. After 15 days and 21 days, observe the hair growth situation of two groups of mice, the inventors found that the bpv (phen) inhibitor treated part hair grows very fast, while other parts hardly have;

[0027] Experimental results: 15 days after the mice were depilated, no hair entered the anagen phase at all, while the areas treated with the inhibitor had already grown hair. Twenty-one days after depilation, the skin of the mice had just begun to darken, while t...

Embodiment 2

[0029] Analyze the phosphorylation of mouse epidermal cells and hair follicle cells treated with bpv (phen) inhibitors:

[0030] 1. Get the skin tissues of bpv (phen) inhibitor treatment group and control group respectively;

[0031] 2. After 4% PFA fixation and sucrose dehydration, perform tissue sectioning;

[0032] 3. Immunofluorescence staining showed that the epidermal cells and hair follicle cells of the mice treated with the inhibitor almost all expressed AKT-P 3 days after depilation, while the epidermal cells and hair follicle cells of the control group almost did not express;

[0033] 4. Experimental results: 3 days after hair removal in mice, the hair follicles were in the telogen stage, and the expression of AKT-P in the hair follicles and their epidermis was very low, almost no expression, while the expression of KAT-P in the hair follicles and epidermis of the inhibitor treated parts was very high , indicating that these cells are activated.

Embodiment 3

[0035] Analysis of bpv (phen) inhibitor treated mouse hair follicle growth cycle and hair follicle stem cell proliferation:

[0036] 1. Get the skin tissues of bpv (phen) inhibitor treatment group and control group respectively;

[0037] 2. After 4% PFA fixation and sucrose dehydration, perform tissue sectioning;

[0038] 3. Immunofluorescence staining showed that the hair follicles in the bpv (phen) inhibitor-treated area entered the anagen phase after 5 days, while the hair follicles in other areas were in the resting phase;

[0039] 4. Experimental results: Immunofluorescence staining of the cell proliferation marker Ki67 showed that hair follicle stem cells proliferated in large numbers after 5 days in the hair follicles treated with bpv (phen) inhibitors, while other control hair follicle stem cells rarely proliferated.

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Abstract

The invention provides a method for promoting hair growth, and belongs to the technical field of beauty or heath care. The method for promoting the hair growth includes the step that a nanometer material serves as a carrier of a small-molecule inhibitor and is injected subcutaneously into skin to promote the hair growth. The method is characterized in that the small-molecule inhibitor can inhibit the activity of pten protein with specificity so that an AKT signal channel can be activated, and thus hair follicle stem cells are activated, and hair follicles enter in a growth period and regrow. The method for promoting the hair growth can enable the hair follicles to be in the growth period for a long time, and can promote hair to regrow while the skin and hair follicle structures are not damaged. The method for promoting the hair growth can be applied to regrowing of hair follicles in a wound and regrowing of head hair, can be applied to promoting growth of hair in body parts, such as a wound and the head skin, and can further be applied to the field of beauty or health care.

Description

technical field [0001] The invention relates to a method for promoting hair growth by activating hair follicle stem cells to proliferate, so that the hair follicle enters anagen and regenerates, and belongs to the technical field of beauty and health care. Background technique [0002] People in the medical field know that hair follicles are formed during embryonic development and undergo repeated cycles of growth (Anagen), regression (Catagen) and rest (Telogen) after birth. In the growth phase, the hair matrix cells (Matrix) rapidly proliferate and differentiate into the hair shaft and the inner root sheath of the hair follicle. When the hair enters the telogen period, the dermal papilla reaches the bulge until the next growth period, and the dermal papilla moves down with the newly generated hair follicle germ (Germ). Hair follicle development and periodic regeneration are intricate molecular regulatory processes. By controlling complex molecular networks and different s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/555A61P17/14
CPCA61K9/0014A61K9/0019A61K31/555
Inventor 王旭升
Owner SHENZHEN TIANYUAN STEM CELL TECH CO LTD
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