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Method for extracting rosmarinic acid from labiates and prepared drug

A plant extract and rosmarinic acid technology, applied in the field of medicine, can solve the problems of high cost, difficulty in obtaining rosmarinic acid, complex process, etc., and achieve the effect of increased utilization, low price and simple process

Inactive Publication Date: 2017-11-24
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In summary, the problems in the prior art are: the current extraction method of rosmarinic acid has complicated process, high cost, and it is not easy to obtain more than 90% rosmarinic acid

Method used

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  • Method for extracting rosmarinic acid from labiates and prepared drug

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Experimental program
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Effect test

Embodiment 1

[0044] Rosemary stems and leaves are crushed into coarse powder, distilled in 10-20 times of water at 40-100 degrees Celsius for 1-2 hours, and the distillate is placed separately to provide volatile oil; the distilled solution is filtered, and directly put on the prepared macroporous resin, That is, on the basis that the content of benzene is less than 1ppm, other solvents such as toluene and xylene should be less than 20ppm, and the total amount of residual organic solvents is less than 100ppm, wash it with 0-20% ethanol water, and then rinse it with 40-60% ethanol until it is free. Residue of marinic acid; reclaim ethanol, use the ultrafiltration membrane technology of molecular weight 400 to obtain the semi-finished product of rosmarinic acid, the above-mentioned semi-finished product is heated to 50 degrees Celsius in pure water with a pH of 3 to 4, dissolve the semi-finished product of rosmarinic acid as much as possible to the net, in Cool in a freezing chamber, crystall...

Embodiment 2

[0046] Rosemary stems and leaves are crushed into coarse powder, distilled in 10-20 times of water at 50-90 degrees Celsius for 1-2 hours, and the distillate is placed separately to provide volatile oil; the distilled solution is filtered and directly put on the prepared medicinal macropore Resin WLD, washed with 0, 20% ethanol in sequence, and then rinsed with 40-60% ethanol until no rosmarinic acid remains; recovering ethanol, using ultrafiltration membrane technology with a molecular weight of 400 to obtain semi-finished products of rosmarinic acid. Heat the pure water with pH 3-4 to 50 degrees Celsius, dissolve the semi-finished product of rosmarinic acid as much as possible to the net, cool it in the freezing room, crystallize, and repeat this process 3 times to obtain pure rosmarinic acid and pure rosmarinic acid. The content is 98%.

Embodiment 3

[0048] Rosemary stems and leaves are crushed into coarse powder, distilled in 14-20 times of water at 90 degrees Celsius for 1-2 hours, and the distillate is placed separately to provide volatile oil; the distilled solution is filtered and directly put on the prepared medicinal macroporous resin SP825 , washed with 0, 20% ethanol water successively, and then rinsed with 60% ethanol until no rosmarinic acid remains; reclaim the ethanol, and use the ultrafiltration membrane technology with a molecular weight of 400 to obtain the semi-finished product of rosmarinic acid until it is clean, and the above-mentioned semi-finished product is at pH3 Heat to 50 degrees centigrade in ~4 pure water, dissolve the semi-finished product of rosmarinic acid as far as possible to the net, cool in the freezing chamber, crystallize, and go back and forth 3 times like this, obtain the pure product of rosmarinic acid, the content of the pure product of rosmarinic acid is 98.2%.

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Abstract

The invention belongs to the technical field of medicines and discloses a method for extracting rosmarinic acid from labiates and a prepared drug. The method comprises the following steps: dissolving a labiate extract containing water-soluble rosmarinic acid in 0%-95% acidic alcohol-water solution, then adding medicinal macro-porous resin and washing by using 0%-20% alcohol-water solution; eluting by using 20%-95% alcohol-water solution, thereby acquiring a crude product of rosmarinic acid; filtering the crude product of rosmarinic acid by adopting an ultra-filtration membrane, thereby acquiring the rosmarinic acid; and repeatedly extracting the rosmarinic acid by using organic and inorganic solvents, concentrating, standing by, crystallizing in an acidic solvent, re-crystallizing and drying, thereby acquiring a pure product of rosmarinic acid. According to the invention, the pure product of rosmarinic acid is acquired according to the steps of passing by macro-porous resin, performing ultra-filtration, repeatedly extracting the rosmarinic acid by using organic and inorganic solvents, concentrating, standing by, crystallizing in the acidic solvent, re-crystallizing and drying. Various drug resources can be used for supplying rosmarinic acid; the technology is simple and convenient, the operation is easy and the cost is low; and the method is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a method for extracting rosmarinic acid from Labiatae plants and a prepared medicine. Background technique [0002] Because the crude product of rosemary has been developed as a food antioxidant and preservative, it is used for antisepsis and antibacterial in oils, fat-rich foods, and other foods and seafood, and is widely used in the chemical industry. Pharmacological research finds that it has many effects but fails to develop into medicine, health product, food, and its reason is that nobody can develop the product of the rosmarinic acid of high purity (more than 98%) on a large scale, and because Chinese medicine chemistry The content of rosmarinic acid in general medicines, health products and foods should be greater than 98%. Therefore, 20 years ago, the State-owned Assets Supervision and Administration Commission invested 15 million yuan to build a 50-ton ro...

Claims

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Application Information

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IPC IPC(8): C07C67/48C07C69/732A61K31/216A61P25/28A61P9/00A61P1/16A61P13/12A61P35/00
CPCA61K31/216C07C67/48C07C69/732
Inventor 邓文龙
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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