Radix scrophulariae aqueous extract and application thereof
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A technology of water extract and scrophulariaceae, applied in the water extract of scrophularia ginseng and its application field, can solve the problems such as the active substance of scrophulariaceae that have not yet been seen
Inactive Publication Date: 2017-12-01
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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Problems solved by technology
So far, there have been no reports and patents on the specific components and applications of the active substances of Scrophulariaceae Scrophulariae
Method used
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Embodiment 1
[0055] 1) Dry the root of Scrophulariaceae Scrophulariae at 80°C-120°C, extract it with water at 60°C-100°C for 1-2 hours, and concentrate under reduced pressure. The relative density of the concentrated solution preferably reaches 2.0-3.0, and the extract is obtained;
[0056] 2) subjecting the extract to non-polar macroporous resin chromatography, and eluting with an aqueous ethanol solution with a volume concentration of 65% to obtain the eluate;
[0057] 3) The eluate is subjected to MCI column chromatography, and is eluted with a volume concentration of 10%, 30%, 60% and 90% methanol water solution to obtain 10%, 30%, 60% and 90% ethanol respectively eluate;
[0058] 4) The ethanol eluate with a volume concentration of 10% was subjected to gel column chromatography, and thin-layer detection was carried out under the condition that the volume ratio of dichloromethane to methanol was 2:1, and tracer combined with high-performance liquid phase. The volume ratio of water is ...
Embodiment 2
[0065] The granules prepared in Example 1 were used in mice with convulsions, sudden deafness, visual impairment or headache symptoms caused by cerebral ischemia
[0066] 1. Model establishment and dosing regimen
[0067] 160 male mice with a body weight of 10-20 g were taken, and middle cerebral artery electrocoagulation was performed according to the literature method to create model mice with convulsions, sudden deafness, visual impairment or headache caused by cerebral ischemia. The mice were randomly divided into 8 groups, namely sham operation group, model group, Xuesaitong group, vinpocetine group, Mailuoning group, high, medium and low dosage groups of Scrophulariaceae Granules, and the other sham operation group In order to find the middle cerebral artery without electrocoagulation, the tail vein was administered once a day for 7 consecutive days.
[0068] 2. Detection indicators
[0069] Determination of infarction index:
[0070]
[0071] Determination of brai...
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Abstract
The invention provides radix scrophulariae aqueous extract and an application thereof and belongs to the technical field of medicine extraction. The radix scrophulariae aqueous extract contains 30 iridoid glycoside compounds. The effective active parts of traditional Chinese medicines are more explicated. The radix scrophulariae aqueous extract primarily has the function of protecting cranial nerves, and can be used for treating cerebral ischemia and cerebral apoplexy. The radix scrophulariae aqueous extract can be used for treating cerebrovascular diseases and cephalagra caused by cerebral ischemia clinically and also can be used for treating symptoms such as cerebral angiospasm, sudden deafness, visual impairment and headache induced by transient cerebral ischemia. Therefore, the radix scrophulariae aqueous extract provided by the invention is expected to provide a modern traditional Chinese medicine preparation with the cranial nerve protecting function. The radix scrophulariae aqueous extract is applied to preparing a medicine for preventing and treating diseases caused by ischemia. Furthermore, the radix scrophulariae aqueous extract is applied to preparing a cranial nerve protecting health-care product for treating clinical related diseases caused by cerebral ischemia in an assisted manner.
Description
technical field [0001] The invention belongs to the technical field of medicine extraction, and in particular relates to a water extract of Scrophularia scrophulariae and its application. Background technique [0002] Cerebrovascular disease is a common disease that seriously endangers human health and is the second leading cause of human death. The incidence rate in my country is 120 / 100,000-180 / 100,000, and 800,000 to 1 million people die every year. Cerebrovascular disease is also the leading cause of disability in the world. More than 75% of surviving patients in my country have disabilities of varying degrees, which brings a heavy burden to families and society. Ischemic cerebrovascular disease is the most common type of cerebrovascular disease (accounting for 60-70%). It is a difficult problem to be solved urgently in clinical medicine. In recent years, it has shown a clear trend of rejuvenation. There are hemorrhages in clinical thrombolysis-based treatment limitatio...
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Application Information
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61P9/10
CPCA61K36/808A61K2236/331A61K2236/55
Inventor 许旭东孙贵波马国需朱乃亮吴海峰胡美庚孙忠浩
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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