A slow-release antibacterial composite bone graft material and its preparation method
A bone-implanted and sustained-release technology, applied in antibacterial drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as weak ability to repair bone defects, achieve long drug release time, lasting local resistance to multidrug-resistant tuberculosis, low cost effect
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[0031] A slow-release antibacterial composite bone graft material of the present invention is mainly made by mixing nano-silver / TMC-207 slow-release microspheres, nano-hydroxyapatite nHA and calcium phosphate bone cement powder CPC, and nano-silver / TMC-207 slowly The volume ratio of release microspheres, nHA, and CPC is 1-3:1-3:6, and in this embodiment, the volume ratio of nano-silver / TMC-207 slow-release microspheres, nHA, and CPC is 1:1:6. Nano-silver / TMC-207 slow-release microspheres are mainly prepared by using nano-silver and TMC-207 as raw materials, PLGA as the carrier material, and prepared by O / O emulsification-solvent evaporation method. The quality of PLGA, nano-silver, and TMC-207 The ratio is 10-20:1:1, and the mass ratio of PLGA, nano-silver, and TMC-207 in this embodiment is 20:1:1. The local anti-tuberculosis ability and osteoinductive performance of the material can be increased by adjusting the ratio of raw materials.
[0032] A preparation method of the sl...
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