A slow-release antibacterial composite bone graft material and its preparation method

A bone-implanted and sustained-release technology, applied in antibacterial drugs, drug combinations, pharmaceutical formulations, etc., can solve problems such as weak ability to repair bone defects, achieve long drug release time, lasting local resistance to multidrug-resistant tuberculosis, low cost effect

Active Publication Date: 2018-06-22
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional CPC has no osteogenic effect, and its ability to repair bone defects is weak, so its biological performance needs to be improved.

Method used

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  • A slow-release antibacterial composite bone graft material and its preparation method
  • A slow-release antibacterial composite bone graft material and its preparation method
  • A slow-release antibacterial composite bone graft material and its preparation method

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Embodiment 1

[0031] A slow-release antibacterial composite bone graft material of the present invention is mainly made by mixing nano-silver / TMC-207 slow-release microspheres, nano-hydroxyapatite nHA and calcium phosphate bone cement powder CPC, and nano-silver / TMC-207 slowly The volume ratio of release microspheres, nHA, and CPC is 1-3:1-3:6, and in this embodiment, the volume ratio of nano-silver / TMC-207 slow-release microspheres, nHA, and CPC is 1:1:6. Nano-silver / TMC-207 slow-release microspheres are mainly prepared by using nano-silver and TMC-207 as raw materials, PLGA as the carrier material, and prepared by O / O emulsification-solvent evaporation method. The quality of PLGA, nano-silver, and TMC-207 The ratio is 10-20:1:1, and the mass ratio of PLGA, nano-silver, and TMC-207 in this embodiment is 20:1:1. The local anti-tuberculosis ability and osteoinductive performance of the material can be increased by adjusting the ratio of raw materials.

[0032] A preparation method of the sl...

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Abstract

The invention discloses a sustained-release antibacterial compound bone grafting material and a preparation method thereof. The sustained-release antibacterial compound bone grafting material is mainly prepared by mixing nanosilver / TMC-207 sustained release microspheres, nano-hydroxyapatite and calcium phosphate cement powder. The preparation method comprises the following steps: firstly, preparing the nanosilver / TMC-207 sustained release microspheres by an O / O emulsion-solvent evaporation method, wherein PLGA is used as a carrier material; secondly, mixing the nanosilver / TMC-207 sustained release microspheres, the nano-hydroxyapatite and the calcium phosphate cement powder, and blending an obtained mixture with deionized water to obtain paste; setting and drying the paste to obtain the slow-release antibacterial compound bone grafting material. The sustained-release antibacterial compound bone grafting material disclosed by the invention has the advantages of long local drug release time, obvious sterilizing effect and high bone repairing capability. The preparation method has the advantages of being simple and convenient to operate and lower in cost.

Description

technical field [0001] The invention belongs to the field of surgical supplies, and relates to an antibacterial bone graft material for surgical supplies and a preparation method thereof, in particular to a slow-release antibacterial (especially anti-tuberculosis) composite bone graft material and a preparation method thereof. Background technique [0002] Multidrug-resistant tuberculosis (MDR-TB) has been spreading worldwide in recent years, and my country is one of the countries with a high prevalence of drug-resistant tuberculosis in the world. MDR-TB is difficult to treat, has a high mortality rate, and has a poor prognosis. Spinal tuberculosis, as the most common extrapulmonary tuberculosis, also faces the problem of multi-drug resistance. If not treated properly, it can lead to prolonged recurrence of the disease and progress to severe kyphosis and neurological disorders. Currently, the conventional treatment regimen for multidrug-resistant spinal tuberculosis is syst...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/04A61L27/12A61L27/18A61L27/50A61K33/38A61K9/50A61K47/34A61P19/08A61P31/06A61P31/04A61K31/47
CPCA61K9/0002A61K9/5031A61K31/47A61K33/38A61L27/047A61L27/12A61L27/18A61L27/50A61L27/54A61L2300/104A61L2300/404A61L2300/412A61L2300/602A61L2300/622A61L2300/624A61L2400/12A61L2430/02C08L67/04A61K2300/00
Inventor 周永春吕红斌胡建中陈灿
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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