Preparation method of high-water solubility florfenicol powder

Abstract

The invention discloses a preparation method of high-water solubility florfenicol powder. The preparation method comprises the following steps: S1, adding 400-500 parts by weight of water, 200-250 parts by weight of beta-cyclodextrin and 20-80 parts by weight of florfenicol by weight into a reaction kettle, stirring and heating to 90 DEG C, preserving heat for 2-5 h at 90-95 DEG C, and keeping stirring during heat preservation to obtain a first mixed solution; S2, cooling the first mixed solution to 10 DEG C, preserving heat for 0.5-1 h at 0-15 DEG C for use, and keeping stirring during heat preservation; S3, centrifuging the first mixed solution treated in the step S2 to obtain first mixed powder and a first mother solution, drying the first mixed powder, and sieving to obtain first florfenicol powder. The invention provides the preparation method of the high-water solubility florfenicol powder, by which the solubility of the florfenicol can be effectively improved.

Description

technical field [0001] The invention relates to the field of preparation of florfenicol powder. More specifically, the present invention relates to a preparation method of highly water-soluble florfenicol powder. Background technique [0002] Florfenicol is an antibacterial drug commonly used in animal breeding and production. It is safe, effective and widely used. However, the solubility of florfenicol in water is very small, and it is not suitable for water-soluble administration, which limits its application in the treatment of animal diseases. Cosolvent micronization, β-cyclodextrin inclusion, hydroxypropyl β-cyclodextrin inclusion, PVPK dispersion, PEG6000 dispersion, ultrafine, grinding and other methods generally have unsatisfactory solubilizing effects, and the dissolution rate is slow, The dissolution rate is small, and it is difficult to meet the needs of preparation and concentrated use. [0003] The initial preparation technology of florfenicol powder is simpl...

AI Technical Summary

Problems solved by technology

Currently on the domestic market, the preparation method of florfenicol powder with good water solubility is mainly through the spray drying method. Although the water solubility of the prepared product has been greatly improved, but according to the Calculated, the solubility at room temperature is about 1200-3000ppm, and this method is used to produce, the production capacity is small, and the energy consumption is high

[0005] CN102160854 has introduced a kind of preparation method of florfenicol powder, and the defect of this method is that the one, clathrate is not thorough, and gained product solubility and bioavailability are not perfect, and the solubility of florfenicol has improved 4 times, is about 1200ppm, which is quite different from the existing technology; second, it is prepared by oven drying, which is labor-intensive and energy-consuming; third, this method needs to add glucose for re-mixing

[0008] CN106177983 has introduced a kind of preparation technology of florfenicol powder, the shortcoming of this method one is to add organic solvent ethanol, only applicable to small-scale preparation, during actual production, also must consider the reclaiming and processing of organic solvent; The 2nd, preparation method Complicated, two kinds of solutions A and B need to be formulated first, and then gradually mixed. In addition, in order to obtain the product, it must be refrigerated for 24 hours, and finally washed with ethanol. The preparation method is complicated and the cycle is too long; It is that the inclusion rate and yield of this method are not ideal, and the inclusion is not complete, and the solubility of the product must be affected; the fourth is that this method is not suitable for large-scale production

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