Method for ultra high-pressure extraction of escin from Chinese buckeye seeds based on freeze drying

A technique for escin and sorrel, which is applied in chemical instruments and methods, preparation of sugar derivatives, steroids, etc., can solve the problems of increased energy consumption and cost, difficult cell wall rupture, and difficult solvent penetration, etc. Energy consumption and cost, the effect of reducing impurities, reducing the cost of extraction

Active Publication Date: 2018-01-19
WUHAN AIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Sala seeds are hard, the cell wall is difficult to break, and the solvent is difficult to penetrate into the medicinal material tissue, resulting in the need for higher pressure (usually more than 500Mpa) and more times (usually more than 3 times of repeated extraction) during ultra-high pressure extraction, thereby increasing the Energy Consumption and Cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Crush the saffron into powder with a particle size of 15 mesh, soak in water for 2 hours, remove it, drain the surface moisture, and place it in a freezer with a temperature of -25°C for rapid freezing;

[0033] (2) Carry out vacuum-drying to the frozen sala seed, the vacuum tightness of controlling drying process is 10pa, and temperature is 40 ℃;

[0034] (3) Add 12 times of weight of 20% ethanol to the dried Salazi, pack into a pressure-resistant, flexible soft bag and seal together, then put into the extraction container of the ultra-high pressure extraction device, extract at normal temperature, extract Proceed as follows:

[0035] 1) Boosting stage: raise the pressure in the extraction container to 200Mpa within 15 minutes;

[0036] 2) Pressure holding stage: keep the pressure for 15 minutes;

[0037] 3) Pressure relief stage: quickly release the pressure to normal pressure within 10s;

[0038] 4) Repeat steps 1)-3) once;

[0039] (4) Take out the soft bag ...

Embodiment 2

[0042] (1) Pulverize the saffron into powder with a particle size of 30 mesh, soak it in water for 3 hours, remove it, drain the water on the surface, and place it in a freezer with a temperature of -30°C for rapid freezing;

[0043] (2) carry out vacuum-drying with the frozen sala seed, the vacuum tightness of controlling drying process is 20pa, and temperature is 50 ℃;

[0044] (3) Add 15 times the weight of water to the dried sala seeds, pack them together into a pressure-resistant, flexible soft bag and seal them, then put them into an ultra-high pressure extraction device, and extract them at normal temperature. The extraction steps are as follows:

[0045] 1) Boosting stage: raise the pressure in the extraction container to 300Mpa within 10 minutes;

[0046] 2) Pressure holding stage: keep the pressure for 10 minutes;

[0047] 3) Pressure relief stage: quickly release the pressure to normal pressure within 15s;

[0048] 4) Repeat steps 1)-3) 2 times;

[0049] (4) Take...

Embodiment 3

[0052](1) Grind the saffron into a powder with a particle size of 10 mesh, soak it in water for 1 hour, remove it, drain the water on the surface, and place it in a freezer at -20°C for rapid freezing;

[0053] (2) Carry out vacuum-drying to the frozen sala seed, the vacuum tightness of controlling drying process is 15pa, and temperature is 30 ℃;

[0054] (3) Add 10 times of weight of 30% ethanol to the dried Sala seeds, pack them together into a pressure-resistant, flexible soft bag and seal them, then put them into the extraction container of an ultra-high pressure extraction device, extract at normal temperature, extract Proceed as follows:

[0055] 1) Boosting stage: raise the pressure in the extraction container to 250Mpa within 15 minutes;

[0056] 2) Pressure holding stage: keep the pressure for 20 minutes;

[0057] 3) Pressure relief stage: quickly release the pressure to normal pressure within 5s;

[0058] 4) Repeat steps 1)-3) 3 times;

[0059] (4) Take out the s...

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Abstract

The invention discloses a method for ultra high-pressure extraction of escin from Chinese buckeye seeds based on freeze drying. The method includes: firstly crushing and soaking Chinese buckeye seed herbal material, then performing freeze drying, and then conducting ultra high-pressure extraction, wherein the extraction step includes a pressure boosting stage, a pressure maintaining stage, a pressure relief stage and the like. According to the invention, Chinese buckeye seeds are subjected to freeze drying treatment to change the internal structure of the herbal material texture, so that cellwalls can rupture more easily, and active ingredients can exude more easily, thereby reducing the pressure and number of times of ultra high-pressure extraction, and lowering energy consumption and cost.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a method for extracting aescin, in particular to a method for extracting aescin based on freeze-drying and extracting aescin by ultra-high pressure from saffron seeds. Background technique [0002] Aescin, also known as aescinic acid, is a general term for total saponins, β-aescin or isoaescin, etc. extracted from the seeds of Aesculus in the family Aescinaceae, belonging to triterpenoid saponins. Aescin has anti-inflammatory, anti-edema and other effects, and is mainly used clinically for the treatment of cerebral edema, trauma and other diseases. At present, most of the extraction of aescin is the method of ethanol thermal reflux or leakage, such as CN 104402963 A, CN 102659897 A, CN 106589045 A, CN104804060 A and other patent documents all adopt this type of method. [0003] With the continuous improvement of traditional Chinese medicine extraction technology, more and more new methods ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/256C07J63/00C07H1/08
Inventor 石召华叶利春张晓存张群烁李群杜文杰张洋
Owner WUHAN AIMIN PHARMA
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