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Pharmaceutical composition for treating Alzheimer's disease, and preparation method of pharmaceutical composition

A technology for Alzheimer's disease and composition, which is applied in the field of medicine, can solve the problems of inability to delay the development of the disease, liver and kidney toxicity of western medicine, and insignificant curative effect, and achieve the effect of treating Alzheimer's disease, broad medical application prospects, and definite curative effect

Inactive Publication Date: 2018-01-23
余必亚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many western medicines for the treatment of senile dementia. These medicines can only temporarily alleviate the cognitive decline of patients, but cannot delay the development of the disease. Moreover, western medicines have serious adverse reactions such as liver and kidney toxicity, and are expensive.
In recent years, experts and scholars at home and abroad have begun to pay attention to natural traditional Chinese medicine. Traditional Chinese medicine has the advantages of strong long-term effect, strong drug resistance, safety and non-toxicity. Alzheimer's Drugs

Method used

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  • Pharmaceutical composition for treating Alzheimer's disease, and preparation method of pharmaceutical composition

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Experimental program
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Effect test

Embodiment 1

[0020] A preparation method for a pharmaceutical composition for treating senile dementia, comprising the steps of:

[0021] S1: Make 10 parts of Epimedium, 7 parts of Rehmannia glutinosa, 7 parts of Chinese yam, 8 parts of ginkgo biloba, 8 parts of safflower, 10 parts of earthworm, and 10 parts of Huhuanglian, add water to decoct 3 times, and filter , combine the filtrates, concentrate the filtrates under reduced pressure to 3 times the amount of raw materials, add ethanol with a mass concentration of 60-70%, stand still for 24-48h, remove the supernatant, concentrate and dry the precipitate under reduced pressure, and pulverize into fine powder for later use;

[0022] S2: Grinding 2 parts of nimodipine and 2 parts of donepezil hydrochloride into fine powder 2;

[0023] S3: Mix the fine powder 2 obtained in step S2 with the fine powder 1 obtained in step S1, add sodium carboxymethyl starch, dextrin, and magnesium stearate, mix evenly, granulate, pack into capsules, and make c...

Embodiment 2

[0025] A preparation method for a pharmaceutical composition for treating senile dementia, comprising the steps of:

[0026] S1: Make 20 parts of Epimedium, 14 parts of Rehmannia glutinosa, 14 parts of Chinese yam, 12 parts of ginkgo biloba, 12 parts of safflower, 12 parts of earthworm, and 12 parts of Huhuanglian, add water to decoct 3 times, and filter , combine the filtrates, concentrate the filtrates under reduced pressure to 3 times the amount of raw materials, add ethanol with a mass concentration of 60-70%, stand still for 24-48h, remove the supernatant, concentrate and dry the precipitate under reduced pressure, and pulverize into fine powder for later use;

[0027] S2: Grinding 3 parts of nimodipine and 3 parts of donepezil hydrochloride into fine powder 2;

[0028] S3: Mix the fine powder 2 obtained in step S2 with the fine powder 1 obtained in step S1, add sodium carboxymethyl starch, dextrin, and magnesium stearate, mix evenly, granulate, pack into capsules, and ma...

Embodiment 3

[0030] A preparation method for a pharmaceutical composition for treating senile dementia, comprising the steps of:

[0031] S1: Make 30 parts of epimedium, 20 parts of Rehmannia glutinosa, 20 parts of Chinese yam, 16 parts of ginkgo biloba, 16 parts of safflower, 15 parts of earthworm, and 15 parts of Huhuanglian, add water to decoct 3 times, and filter , combine the filtrates, concentrate the filtrates under reduced pressure to 3 times the amount of raw materials, add ethanol with a mass concentration of 60-70%, stand still for 24-48h, remove the supernatant, concentrate and dry the precipitate under reduced pressure, and pulverize into fine powder for later use;

[0032] S2: Grinding 4 parts of nimodipine and 6 parts of donepezil hydrochloride into fine powder 2;

[0033] S3: Mix the fine powder 2 obtained in step S2 with the fine powder 1 obtained in step S1, add sodium carboxymethyl starch, dextrin, and magnesium stearate, mix evenly, granulate, pack into capsules, and ma...

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Abstract

The invention relates to a pharmaceutical composition for treating Alzheimer's disease, and a preparation method of the pharmaceutical composition. The pharmaceutical composition is prepared by compounding a traditional Chinese medicine component and a western medicine component, wherein the traditional Chinese medicine component is prepared from the following raw material medicines in parts by weight: 10-30 parts of epimedium herb, 5-20 parts of radix rehmanniae preparata, 5-20 parts of rhizoma dioscoreae, 8-16 parts of folium ginkgo, 8-16 parts of safflower, 10-15 parts of lumbricus and 10-15 parts of rhizoma picrorhizae; the western medicine component is prepared from the following raw material medicines: 2-4 parts of nimodipine and 2-6 parts of donepezil hydrochloride. The pharmaceutical composition for treating the Alzheimer's disease is prepared by adopting a method of combining traditional Chinese medicines and western medicines; the multiple Chinese herbal medicines and westernmedicines are selected and combined, thus realizing a synergistic effect and further enhancing the treatment effect on the Alzheimer's disease; the pharmaceutical composition has the functions of resisting aging and improving memory, can be used for effectively treating the Alzheimer's disease, and is obvious in curative effect and low in side effects, thus having a wide medical application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating senile dementia and a preparation method thereof. Background technique [0002] As the pace of the world's aging society continues to accelerate, various neurodegenerative senile diseases, such as mild cognitive impairment and senile dementia, have become important risk factors that threaten human health in old age and reduce the quality of life of the elderly. It has brought serious economic burden and heavy mental pressure to society and family. Alzheimer's disease can be divided into Alzheimer's disease (AD), vascular dementia (VD), mixed dementia (AD+VD) and other dementias. It is a persistent high-level neurological activity disorder, clinically manifested as deteriorating cognitive and memory functions, progressive decline in the ability of daily life, and various neuropsychiatric symptoms and behavioral disorders. Al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P25/28A61K35/62A61K31/4422A61K31/445
Inventor 余必亚
Owner 余必亚
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