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Complex composition containing p-hydroxyacetophenone as well as preparation method and application thereof

A technology of p-hydroxyacetophenone and compound composition, applied in the direction of botanical equipment and methods, detergent composition, application, etc., can solve the problems of reduced convenience, long-term dissolution, high addition amount, etc., and achieve enhanced inhibition Effect, wide antibacterial spectrum, low cost effect

Active Publication Date: 2018-01-26
BEIJING SUNPU BIOCHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, p-hydroxyacetophenone needs to be added in a high amount when used alone, and its water solubility is about 1%. It takes a long time to dissolve when used, which reduces the convenience of application.

Method used

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  • Complex composition containing p-hydroxyacetophenone as well as preparation method and application thereof
  • Complex composition containing p-hydroxyacetophenone as well as preparation method and application thereof
  • Complex composition containing p-hydroxyacetophenone as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-11

[0024] The compound composition containing p-hydroxyacetophenone is a liquid preparation, and its components include p-hydroxyacetophenone, synergist, solubilizer and solvent; the dosage ratio of each component is shown in Table 1.

[0025] The preparation method comprises: adding p-hydroxyacetophenone and solvent into a container according to the proportion and stirring evenly, then adding a synergistic agent and a solubilizer according to the proportion, stirring until they are all dissolved, and then the preparation is obtained.

[0026] Table 1 contains the content of each component of the compound composition of p-hydroxyacetophenone (parts by weight)

[0027]

experiment example 1

[0029] Investigate respectively embodiment 5 (being formula 5#) embodiment 6 (being formula 6#), embodiment 7 (being formula 7#), embodiment 9 (being formula 9#), embodiment 10 (being formula 10#) Low temperature stability of compound composition containing p-hydroxyacetophenone.

[0030] Experimental method: observe each composition above at room temperature (20° C.) and 4° C. for 24 hours, respectively. The results are shown in Table 2.

[0031] Table 2 Composition Low Temperature Stability

[0032]

[0033] In Table 2, comparing 6# with 5#, it can be seen that the formula added with solubilizer is more stable under refrigerated and frozen environments, indicating that solubilizer can simultaneously improve the solubility of p-hydroxyacetophenone at normal temperature and low temperature. It has practical significance in product use and preservation. Simultaneously this solubilization effect has certain limit, as embodiment 10#, when p-hydroxyacetophenone content is hi...

experiment example 2

[0035] Investigate the water solubility and stability of pure p-hydroxyacetophenone and embodiment 4 (ie formula 4#) containing p-hydroxyacetophenone complex composition respectively.

[0036] Experimental method: Prepare an aqueous solution according to the table below at room temperature (25°C), and observe after refrigerated at 4°C for 24 hours. The results are shown in Table 3.

[0037] Table 3 Solubility and Stability

[0038]

[0039] It can be seen from Table 3 that the pure product of p-hydroxyacetophenone has a low solubility in water and a long dissolving time, and after recombination, the solubility is not only improved (converted after the dissolution of formula 4# in embodiment 4, p-hydroxyacetophenone is soluble in water About 1.5%), and the stability of the solution is also greatly improved, fully meeting the production needs, which is of great significance in practical applications.

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PUM

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Abstract

The invention discloses a complex composition containing p-hydroxyacetophenone as well as a preparation method and an application thereof. The complex composition comprises the following components inparts by weight: 10-50 parts of p-hydroxyacetophenone, 5-30 parts of a synergic additive, 0-20 parts of a solubilizer and 25-70 parts of a solvent. The complex composition disclosed by the inventionhas an excellent inhibiting effect on bacteria, molds and saccharomycetes. The product is wide in applicability and low in cost, the dissolubility and stability of the p-hydroxyacetophenone in the solvent are improved due to use of the solubilizer, and the synergic additive can assist in improving the antibacterial effect of the formula, so that the corrosion prevention requirements of household chemicals are met.

Description

technical field [0001] The invention relates to a compound composition containing p-hydroxyacetophenone, a preparation method and application thereof. Background technique [0002] Preservatives are cosmetic raw materials with high risk and restricted (permitted) use. As a must-added ingredient in cosmetics, its safety is always controversial. Some traditional preservatives, such as formaldehyde and its sustained-release products, isothiazolinones, paraben esters, IPBC, triclosan, etc. are often pushed to the forefront of public opinion, making consumers resistant to preservatives The price remains high, and cosmetics manufacturers have fewer and fewer choices. Following that, cosmetics manufacturers around the world have successively launched various concept products of "no XX preservatives", "zero additives" and "no additives", trying to make consumers more aware of the safety of their products. [0003] This trend has brought attention to cosmetic raw materials that are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N35/04A01N31/02A01P1/00A01P3/00C11D3/60C11D3/48C11D3/20A61K8/92A61K8/86A61K8/35A61K8/34A61Q19/00
Inventor 张慧明冯士清赵华许文波
Owner BEIJING SUNPU BIOCHEM TECH
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