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Lubricating coating for surface of medical instrument and application of lubrication coating

A technology of medical devices and coatings, which is applied in the field of medical devices, can solve problems such as poor firmness, and achieve the effects of lubricity, practicability and broad market prospects

Active Publication Date: 2018-01-30
MICROPORT SINICA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a lubricating coating for the surface of medical equipment, which is used to solve the problem of poor firmness of the lubricating coating for the surface of medical equipment at present

Method used

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  • Lubricating coating for surface of medical instrument and application of lubrication coating
  • Lubricating coating for surface of medical instrument and application of lubrication coating
  • Lubricating coating for surface of medical instrument and application of lubrication coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1 Lubricating coating formula for medical device surface

[0055] The lubricating coating for the surface of the medical device comprises a hydrophilic polymer, a carbonyl-containing compound, a hydrazide cross-linking agent and a dispersion medium. Eighteen paint formulations are given in Table 1.

[0056] Table 1 Coating Formulation

[0057]

[0058]

[0059] The components of the paint are stored separately, and are temporarily configured for spraying when used, and the storage period is 24 hours.

Embodiment 2

[0064] The preparation of the hydrophilic coating on the surface of embodiment 2 medical device

[0065] Put polyvinylpyrrolidone and N-vinylpyrrolidone-acrylic acid copolymer in the container according to the ratio of formula 1; then add ethanol into the container; then add dihydrazide carbonate and triethylamine into the container, wait for the container to After a homogeneous mixture had formed, the solution formulation was complete. Spray the prepared solution onto the surface of the medical device, heat and cure it in an oven, the curing temperature is 60-130°C, and form a hydrophilic coating on the surface of the medical device with a lubricating coating on the surface of the medical device. 10-30μm.

Embodiment 3

[0066] Embodiment 3 lubricity and firmness test experiment

[0067] The method of Example 2 was used to coat part of the paint formulation in Example 1 on the catheter substrate, and the friction force outside the catheter was tested 20 times to investigate the firmness and durability of the coating. The lower the friction, the better the lubricity; after 20 times of friction, the lower the friction, the smaller the change, indicating that the coating is less abrasive, that is, the coating has better firmness. Samples were prepared after coating or not coating the coating formulations involved in the present invention on different catheter substrates, and a positive pressure of 300gf was applied to the samples, and the friction force was tested in a water bath environment at 37°C. The experimental results are given in Table 2.

[0068] Table 2 The friction results of different materials after 20 times

[0069]

[0070]

[0071] " / *" in Table 2 indicates that the fricti...

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Abstract

The invention belongs to the field of medical instruments, and particularly relates to a lubricating coating for the surface of a medical instrument and an application of the lubrication coating. Thecoating comprises a hydrophilic polymer, a carbonyl-containing polymer monomer, a hydrazide cross-linking agent and a dispersing medium. The hydrophilic coating on the surface of a medical instrumentcomprises a hydrophilic polymer, a carbonyl-containing polymer and a hydrazide cross-linking agent. According to the technical scheme provided by the invention, an interpenetrating network of the hydrophilic polymer and a supporting polymer is formed on the surface of the medical instrument; the formed coating exhibits high lubricity in a liquid environment; and due to the hydrazone bond in the supporting polymer, the coating layer shows the firmness of attachment to the base body at the same time. Compared with the prior art, after 20 times of friction experiments, the lubricity is not reduced obviously, so that the IPN interpenetrating network method used for increasing the lubricity of the surface of the medical instrument has higher practicability, and has a very wide market prospect.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a lubricating coating for the surface of a medical device and its application. Background technique [0002] Interventional diagnosis and treatment technology is a medical technology that can accurately reach the lesion for diagnosis and treatment under the guidance of imaging equipment such as X-ray, CT and MR, using specific medical devices with little or no damage to human tissue. Interventional medical devices need to be interspersed in or between human tissues, so their surface lubrication performance is one of the important properties of interventional medical devices. [0003] Therefore, researchers are committed to the development of interventional medical device materials with high surface lubricity and low frictional resistance. Polyethylene has the characteristics of good biocompatibility, low toxicity, low coefficient of friction, and high lubricity, so it ...

Claims

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Application Information

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IPC IPC(8): C09D139/06C09D129/00C09D101/28C09D105/08C09D177/00C09D4/02C09D4/06C09D7/63C08J7/04
Inventor 王婷李俊菲陈陆胡燕罗七一
Owner MICROPORT SINICA CO LTD
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