Biopharmaceutical production process continuous sterilization automatic control system and technological process thereof

Abstract

The invention discloses a biopharmaceutical production process continuous sterilization automatic control system, which comprises a first dosing tank, a second dosing tank, a maintaining tank, a steamejector, a first-stage heat exchanger and a second-stage heat exchanger. The steam ejector, the maintaining tank, the first-stage heat exchanger and the second-stage heat exchanger are successively connected through pipelines. The steam ejector, the first dosing tank and the second dosing tank are successively connected through pipelines. Two elevator pumps are connected between the steam ejectorand the second dosing tank. A cut-off check valve, a temperature sensor, a material regulating valve, a material flowmeter and a post-pumping valve are successively connected between the steam ejector and the two elevator pumps. Heating time of a culture medium is short, less nutritional ingredients are destroyed, and fermentation efficiency is high. 40-60% steam can be saved, and use amount of circulating water can be saved. The degree of automation is high; labor intensity is reduced; human factors are reduced, thus being beneficial to production quality consistency of various batches. By regulating a technical formula, raw materials can be saved and output can be increased.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to an automatic control system for continuous sterilization in the production process of biopharmaceuticals and a process flow thereof. Background technique [0002] China is an important producer of biopharmaceuticals, and the fermentation industry is an important industry in the national economy and a technology-intensive industry. Although my country is a big country in the production of biological fermentation, the automatic control technology in this industry is relatively backward. Many manufacturers still use manual control in production, and the computer control technology started late and the penetration rate is not high. With the development of the fermentation industry and the expansion of production scale, the fermentation industry is facing increasingly fierce competition, and it is increasingly necessary to rely on automatic detection of the ferm...

AI Technical Summary

Problems solved by technology

At present, domestic pharmaceutical factories generally adopt the intermittent sterilization method, which has the following disadvantages: 1. The medium is heated for a long time, the nutrients are greatly damaged, and the fermentation efficiency is low; 2. The steam consumption is large; 3. The labor intensity of the operators Large, high labor costs; 4. At the same time, there are many human factors involved, and the consistency of production quality in each batch cannot be guaranteed

At present, the sterilization of medium in the domestic bio-fermentation industry is mainly carried out by intermittent sterilization methods. Although a small number of production companies have adopted continuous sterilization methods, they have not conducted in-depth research on the automatic control technology of continuous sterilization, which cannot meet the requirements of production enterprises. production requirements

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