Method for detecting acetaminophen and other chemicals in herbal beverage

A technology for acetaminophen and herbal beverages, which is applied in the field of detecting acetaminophen and other chemical drugs in herbal beverages, can solve problems such as inability to supervise the quality of herbal beverages, rapid determination of chemical drugs, etc., and meet high-throughput screening requirements. , The effect of fast detection and simple operation

Inactive Publication Date: 2018-02-02
广东省药品检验所
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is currently no effective method for rapid determination of illegally added chemicals in

Method used

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  • Method for detecting acetaminophen and other chemicals in herbal beverage
  • Method for detecting acetaminophen and other chemicals in herbal beverage
  • Method for detecting acetaminophen and other chemicals in herbal beverage

Examples

Experimental program
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Effect test

preparation example Construction

[0020] 1) Preparation of herbal beverage sample solution: dissolve the solid herbal beverage with methanol solution, and dilute the liquid herbal beverage with methanol solution to obtain the herbal beverage sample solution;

[0021] 2) Preparation of a series of control sample solutions: first prepare acetaminophen into a standard stock solution with methanol solution, then take several standard stock solutions and dilute to different multiples with methanol solution to obtain a series of control sample solutions;

[0022] 3) making of standard curve: the serial control sample solution is injected in the high-performance liquid chromatograph respectively, obtains chromatogram, measures peak area, is abscissa with the concentration of series control sample solution, and peak area is ordinate, draws standard curve, get the regression equation;

[0023] 4) Determination of herbal beverage sample solution: inject the herbal beverage sample solution into a high-performance liquid ...

Embodiment 1

[0033] A method for measuring the concentration of acetaminophen and other chemical drugs in a solid herbal beverage, comprising the following steps:

[0034] 1) Preparation of herbal beverage sample solution: Grind and mix the solid herbal beverage, weigh 0.3g, add to a 50mL volumetric flask, add methanol solution, ultrasonically extract for 15 minutes, let stand, add water to volume, shake well, filter, Filtrate is herbal beverage sample solution; (the concentration of methanol solution is 550g / L)

[0035] 2) Preparation of a series of control sample solutions: Paracetamol is first prepared into a standard stock solution with a concentration of 50 mg / L with methanol solution, and then 6 parts of standard stock solutions are taken and diluted to different multiples with methanol solution to obtain paracetamol Phenol concentration is successively the series control sample solution of 1mg / L, 5mg / L, 10mg / L, 20mg / L, 30mg / L and 50mg / L; (the concentration of methanol solution is 55...

Embodiment 2

[0056] A method for measuring the concentration of acetaminophen and other chemical drugs in liquid herbal beverages, comprising the steps of:

[0057] 1) Preparation of the herbal beverage sample solution: Shake the liquid herbal beverage evenly, weigh 5mL, add it to a 25mL volumetric flask, add methanol solution to constant volume, and shake well to obtain the herbal beverage sample solution; (the concentration of the methanol solution is 550g / L )

[0058] 2) Preparation of a series of control sample solutions: Paracetamol is prepared into a standard stock solution with a concentration of 50 mg / L with methanol solution, and then 5 parts of standard stock solutions are taken and diluted to different multiples with methanol solution to obtain paracetamol Phenol concentration is successively the serial control sample solution of 5mg / L, 10mg / L, 20mg / L, 30mg / L and 50mg / L; (the concentration of methanol solution is 550g / L)

[0059] 3) making of standard curve: the serial control ...

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Abstract

The invention discloses a method for detecting acetaminophen and other chemicals in a herbal beverage. The method comprises the following steps: 1) preparing a herbal beverage sample solution; 2) preparing a series of control sample solutions; 3) making a standard curve; and 4) determining the herbal beverage sample solution. The detection method has the advantages of simplicity in operation, fastdetection speed, good precision and high sensitivity, meets high-throughput screening requirements, and fills in the gap in the detection of acetaminophen and other chemicals in the herbal beverage at present.

Description

technical field [0001] The invention relates to a method for detecting acetaminophen and other chemical drugs in herbal beverages. Background technique [0002] Herbal beverage is a popular beverage in southern China (Guangdong, Guangxi, Fujian and other places). It is guided by the theory of health preservation in traditional Chinese medicine and uses Chinese herbal medicines as raw materials. Herbal beverages are a kind of common food, but some unscrupulous businesses add antipyretic and analgesic drugs to herbal beverages to enhance the efficacy of herbal beverages, thereby increasing product sales, which brings safety hazards to consumers’ health. Seriously disrupt the development of the herbal beverage industry. In the past ten years, the phenomenon of adding chemical drugs to Chinese patent medicines, health food, cosmetics and food has become more and more serious, and supervision should be strengthened and severe crackdown should be carried out. However, there is c...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 温家欣
Owner 广东省药品检验所
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