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Combinatorial medicine for trabeculectomy, preparation method and application thereof

A technology of resection and medicine, which is applied in the field of medicine, can solve the problems that the lidocaine preparation is easily diluted and not enough to maintain the anesthesia effect, the dosage is difficult to control, and the steps are cumbersome, etc., and achieve the effect of avoiding surgical site configuration, rapid dissolution, and uniform distribution

Inactive Publication Date: 2018-02-09
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the problems that the existing mitomycin C preparations in clinical practice are cumbersome, easily polluted, and the dosage is not easy to control, and lidocaine preparations are easily diluted in ophthalmic operations and cannot maintain the anesthesia effect. Combination medicine, preparation and application of mycin C and lidocaine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A combination drug that differs in that it includes Mitomycin C, Lidocaine, Hydroxypropyl-β-Cyclodextrin, Poloxamer 407, Poloxamer 188, Carbomer, Manna Alcohol, Propylene Glycol, Sodium Metabisulfite, EDTA-2Na, Methylparaben, Propylparaben.

[0023] The mass percent of each component is as follows

[0024] Mitomycin: 0.3%, Lidocaine: 0.5%, Hydroxypropyl-β-cyclodextrin: 4%, Poloxamer 407: 5%, Poloxamer 188: 2%, Carbomer: 0.03%, Mannitol: 3%, Propylene Glycol: 1%, Sodium Metabisulfite: 0.1%, EDTA-2Na: 0.01%, Methylparaben: 0.02%, Propylparaben: 0.03%.

[0025] The preparation method of the combination medicine is different in that it comprises the following steps:

[0026] Step 1), Mitomycin C, lidocaine, hydroxypropyl-β-cyclodextrin, poloxamer 407, poloxamer 188, carbomer, mannitol, propylene glycol, sodium metabisulfite, EDTA -2Na, methyl p-hydroxybenzoate, and propyl p-hydroxybenzoate were added in a certain proportion to obtain 100L initial solution of the combined...

Embodiment 2

[0033] A combination drug that differs in that it includes Mitomycin C, Lidocaine, Hydroxypropyl-β-Cyclodextrin, Poloxamer 407, Poloxamer 188, Carbomer, Manna Alcohol, Propylene Glycol, Sodium Metabisulfite, EDTA-2Na, Methylparaben, Propylparaben.

[0034] The mass percent of each component is as follows

[0035] Mitomycin: 0.4%, Lidocaine: 2%, Hydroxypropyl-β-cyclodextrin: 5.7%, Poloxamer 407: 6%, Poloxamer 188: 3%, Carbomer: 0.06%, Mannitol: 5%, Propylene Glycol: 1.5%, Sodium Metabisulfite: 0.1%, EDTA-2Na: 0.02%, Methylparaben: 0.03%, Propylparaben 0.05%.

[0036] The preparation method of the combination medicine is different in that it comprises the following steps:

[0037] Step 1), Mitomycin C, lidocaine, hydroxypropyl-β-cyclodextrin, poloxamer 407, poloxamer 188, carbomer, mannitol, propylene glycol, sodium metabisulfite, EDTA -2Na, methyl p-hydroxybenzoate, and propyl p-hydroxybenzoate were added in a certain proportion to obtain 100L initial solution of the combine...

Embodiment 3

[0043] A combination drug that differs in that it includes Mitomycin C, Lidocaine, Hydroxypropyl-β-Cyclodextrin, Poloxamer 407, Poloxamer 188, Carbomer, Manna Alcohol, Propylene Glycol, Sodium Metabisulfite, EDTA-2Na, Methylparaben, Propylparaben.

[0044] The mass percent of each component is as follows

[0045] Mitomycin: 0.5%, Lidocaine: 3%, Hydroxypropyl-β-cyclodextrin: 6%, Poloxamer 407: 7%, Poloxamer 188: 4%, Carbomer: 0.06%, mannitol: 6%, propylene glycol: 2%, sodium metabisulfite: 0.3%, EDTA-2Na: 0.03%, methylparaben: 0.04%, propylparaben 0.06%.

[0046] The preparation method of the combination medicine is different in that it comprises the following steps:

[0047] Step 1), Mitomycin C, lidocaine, hydroxypropyl-β-cyclodextrin, poloxamer 407, poloxamer 188, carbomer, mannitol, propylene glycol, sodium metabisulfite, EDTA -2Na, methyl p-hydroxybenzoate, and propyl p-hydroxybenzoate were added in a certain proportion to obtain 100L initial solution of the combined dr...

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PUM

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Abstract

The invention provides a combinatorial medicine for trabeculectomy. The combinatorial medicine is prepared from mitomycin C, lidocaine, hydroxypropyl-beta-cyclodextrin, Poloxamer 407, Poloxamer 188, carbomer, mannitol, propylene glycol, sodium metabisulfite, EDTA-2Na, methylparaben, and propylparaben. The invention provides a preparation method of the combinatorial medicine for trabeculectomy andapplication of the combinatorial medicine in preparing a preparation for trabeculectomy. The preparation can prevent scars or has a surface anesthesia role in trabeculectomy. The combinatorial medicine reduces operation pollution, makes mitomycin C and lidocaine more stable, and delivers better effects in preventing scars and anesthetizing compared with the medicine using mitomycin C and lidocainealone.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a combined medicine for trabeculectomy, a preparation method and application thereof. Background technique [0002] Glaucoma, as the second leading cause of blindness in the world, is a serious threat to human visual health. Trabeculectomy is a classic surgical procedure for the treatment of primary glaucoma. A new extraocular drainage channel is established in the corneal limbus to drain aqueous humor from the anterior chamber to the subconjunctival space and be absorbed by surrounding tissues, thereby controlling intraocular pressure and improving visual acuity. Function. The scleral plate covers the drainage port, restricts the excessive outflow of aqueous humor, and reduces the postoperative hypotension of the anterior chamber and the accompanying complications to a certain extent. The intraocular pressure control rate of trabeculectomy is 75%. The main reason a...

Claims

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Application Information

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IPC IPC(8): A61K31/407A61K31/167A61K47/40A61P27/06A61P17/02A61P23/02
Inventor 沈吟童妍卢苇
Owner WUHAN UNIV
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