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Medicine composition for treating hemorrhoids, medicinal preparations and application

A technology for pharmaceutical preparations and compositions, applied in the field of pharmaceutical preparations for treating hemorrhoids, can solve the problems of unclear active ingredients and their mechanism of action, large dosage, etc., and achieve the effects of improving side effects and fast curative effect.

Inactive Publication Date: 2018-02-09
贵州拜特制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defects of large dosage of Chinese herbal medicines, active ingredients and unclear mechanism of action in existing hemorrhoid products, and to provide a pharmaceutical composition for treating hemorrhoids with rapid curative effect, safety and quality controllable, Pharmaceutical preparations and their applications

Method used

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  • Medicine composition for treating hemorrhoids, medicinal preparations and application
  • Medicine composition for treating hemorrhoids, medicinal preparations and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the preparation of A1 suppository

[0030] Prescription: loganin 0.48g, matrine 0.53g, berberine 1.39g, cortex 0.13g, gallic acid 61.38, osthole 2.13g, sweet potato vine total flavonoids 5.05g

[0031] Preparation method: take the formula amount of loganin, matrine, berberine, cortex, gallic acid, osthole, sweet potato vine total flavonoids, mix thoroughly and set aside; take another suppository base to make up the total amount of 637.5g, mix , heated and melted on a water bath, mixed with the above-mentioned thick ointment and medicated powder, and cast into molds to obtain 425 suppositories, each weighing 1.5g; the matrix is ​​polyethylene glycol 4000 and polyethylene glycol 6000 in a mass ratio of :1 mixture. Approximately 0.17g of active ingredient per capsule.

Embodiment 2

[0032] Embodiment 2: the preparation of A2 suppository

[0033] Prescription: loganin 0.58g, matrine 0.60g, berberine 1.25g, cortex 0.14g, gallic acid 57.42g, osthole 2.39g, sweet potato vine total flavonoids 5.59g

[0034] Preparation method: take the formula amount of loganin, matrine, berberine, cortex, gallic acid, osthole, sweet potato vine total flavonoids, mix thoroughly and set aside; take another suppository base to make up the total amount of 637.5g, mix , heated and melted on a water bath, mixed with the above-mentioned thick ointment and medicated powder, and cast into molds to obtain 425 suppositories, each weighing 1.5g; the matrix is ​​polyethylene glycol 4000 and polyethylene glycol 6000 in a mass ratio of : Mixture of 1.2. Each capsule contains about 0.16g of active ingredient.

Embodiment 3

[0035] Embodiment 3: the preparation of B lotion

[0036] Prescription: loganin 0.53g, matrine 0.56g, berberine 1.32g, cortex 0.13g, gallic acid 59.4g, osthole 2.26g, sweet potato vine total flavonoids 5.32g

[0037] Preparation method: Take the formula amount of loganin, matrine, berberine, cortex, gallic acid, osthole, sweet potato vine total flavonoids, add 80% of the total amount of purified water, 0.5% of sodium benzoate, mix well , add water to a total of 1000ml, that is. Each bottle contains 125ml, and the active ingredient is about 0.07g per ml.

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Abstract

The invention relates to a medicine composition for treating hemorrhoids, medicinal preparations and application. The medicine composition and the medicinal preparations contain individual ingredients, such as honeysuckle stem, lightyellow sophora root, cortex phellodendri and Chinese gall. The medicine composition is prepared from 0.40 to 0.66 part by weight of loganin, 0.47 to 0.66 part by weight of matrine, 1.15 to 1.48 parts by weight of berberine, 0.12 to 0.16 part by weight of phellodendrine, 53.46 to 65.34 parts by weight of gallic acid, 1.86 to 2.66 parts by weight of osthole and 4.79to 5.85 parts by weight of total digua fig stem and leaf flavone. All the individual Chinese herbal medicine ingredients are chosen, excipients are added, and the medicinal preparations are prepared according to conventional preparation processes. The medicine composition and the medicinal preparations prepared therefrom disclosed by the invention have the effects of removing toxin and eliminatingdampness and stopping bleeding and astringing sores, and can achieve a good therapeutic effect when applied to internal hemorrhoids, external hemorrhoids and mixed hemorrhoids caused by the syndromeof accumulated dampness-heat and manifested uncomfortable symptoms such as bleeding, swelling, pain and itching, moreover, toxicity is low, and therefore the medicine composition and the medicinal preparations are ideal medicines.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations for treating hemorrhoids, in particular to a pharmaceutical composition for hemorrhoids, which can detoxify, dry dampness, astringe and stop bleeding, pharmaceutical preparations and applications. Background technique [0002] Hemorrhoids are common names for anorectal diseases such as hemorrhoids, anal fistula, anal fissure, prolapse of the anus, constipation, blood in the stool, and are common and frequently-occurring diseases unique to humans. According to relevant census data, the incidence rate of anorectal diseases such as hemorrhoids is 59.1%, wherein hemorrhoids account for 87.2% of all anorectal diseases, and hemorrhoids are the most common internal hemorrhoids, accounting for 52.19% of all anorectal diseases. Both men and women can get the disease. The incidence rate of women is 67%, and the incidence rate of men is 53.9%. The incidence rate is higher than that of wo...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61P9/14A61P7/04A61P29/00A61P17/04A61K31/7048A61K31/4375A61K31/192A61K31/37
CPCA61K31/192A61K31/37A61K31/4375A61K31/7048A61K36/60A61K2300/00
Inventor 薛捷田紫平国静毛玉莲苟维邱从喜
Owner 贵州拜特制药有限公司
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