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Process for clarification of pharmaceutical composition having face couperose skin treatment effect and quality control method

A quality control method, facial red bloodshot technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Inactive Publication Date: 2018-02-09
GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no relevant reports at home and abroad that the composition of pearl grass, chrysanthemum chrysanthemum, Tianjihuang, gynostemma, centella asiatica, Malan, mulberry leaf and Bawangbian is used to treat facial redness

Method used

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  • Process for clarification of pharmaceutical composition having face couperose skin treatment effect and quality control method
  • Process for clarification of pharmaceutical composition having face couperose skin treatment effect and quality control method
  • Process for clarification of pharmaceutical composition having face couperose skin treatment effect and quality control method

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Embodiment Construction

[0054] A clarification process and quality control method of a pharmaceutical composition with the effect of treating facial red bloodshots according to the present invention, the clarification process is carried out as follows:

[0055] Clarification process and content of each component

[0056] (1) Preparation of clarifying agent: Type II ZTC1+1 natural clarifying agent consists of A and B components. Component A: Precisely measure 1.0g of component A, add a small amount of distilled water, stir to form a paste, then add distilled water to prepare 100mL of viscose, swell for 24 hours, and filter with double gauze. Component B: Precisely measure 1.0g of component B, add a small amount of 1% acetic acid solution by volume, stir to form a paste, then add 1% acetic acid solution to make 100mL viscose solution, swell for 24 hours, Filter with double gauze, that is, too.

[0057] (2) Adding order of clarifiers A and B: According to the instructions, ZTC natural clarifier mainly...

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Abstract

The invention discloses a process for clarification of a pharmaceutical composition having a face couperose skin treatment effect and a quality control method. The pharmaceutical composition is composed of pearl grass, polygala fallax hemsl, herba hyperici japonica, fiveleaf gynostemma herb, centella asiatica, Indian kalimeris herb, mulberry leaves and euphorbia royleana. The concrete process forclarification is to clarify pharmaceutical composition extract with a type II ZTC 1+1 natural clarifying agent. The specific quality control method is to use thin layer chromatography to perform thin-layer identification on pearl grass, Indian kalimeris herb and euphorbia royleana in the pharmaceutical composition, and to measure contents of tenuigenin, vincetoxicoside, gypenoside XVI, asiaticoside and chlorogenic acid in the pharmaceutical composition. The process for clarification and the quality control method have the advantages that the equipment investment is less, an operation process is simple, the shortcomings that a conventional alcohol precipitation method is large in alcohol consumption amount, alcohol recycling is complex and methods for measuring multiple ingredients of medicines are complex are overcome, intrinsic quality, efficacy and stability are ensured rapidly and effectively, and quality standards controllability of the pharmaceutical composition is improved.

Description

technical field [0001] The present invention adopts a clarification process using a natural clarifier and a modern analysis and detection instrument to detect traditional Chinese medicine preparations. The technical field relates to a clarification process and a quality control method for a pharmaceutical composition that has the effect of treating facial red bloodshots. Background technique [0002] Facial red blood streaks, also known as facial telangiectasia in medicine, means that the elasticity of the capillary wall decreases, the fragility increases, and the blood vessels continue to expand unevenly or even rupture, resulting in redness of the facial skin and dilated capillaries visible to the naked eye. Accompanied by red or purple spots, dots, lines or stars, etc., called telangiectasia. (DomingoDS, Camouse MM, Hsia AH, Matsui M, Maes D, Ward NL, Cooper KD, Baron ED. Anti-angiogenic effects of epigallocatechin-3-gallate in human skin. Int J Clin ExpPathol, 2010, 3 (7...

Claims

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Application Information

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IPC IPC(8): A61K36/69A61P9/14G01N30/02G01N30/90
CPCA61K36/185A61K36/23A61K36/28A61K36/424A61K36/47A61K36/605A61K36/69A61K2236/19A61K2236/333A61K2236/53A61K2236/55G01N30/02G01N30/90A61K2300/00
Inventor 王恩瀚陈文龙陈汉坤
Owner GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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