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Method for producing 3D printed artificial bone

A 3D printing and manufacturing method technology, which is applied in the medical field, can solve the problems of drugs staying in the place where they need to be effective, increasing bone mass, and failing to meet the requirements of orthopedic surgery, achieving precise slow-release drug release effects and increasing bone mass. Effect

Pending Publication Date: 2018-02-09
迈海新型材料科技(固安)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The embodiment of the present application provides a manufacturing method of 3D printing artificial bone, which solves the problem that the prior art cannot meet the requirements of various types of orthopedic surgery due to the absence of a bone window closure system, and at the same time, due to the lack of a bone window closure system, makes The technical problem of drug outflow and the inability to keep the drug in the place where it needs to play a role has been achieved. According to 3D printing, the structure of the artificial bone and the bone window is consistent, which is conducive to the sealing of the drug and will not allow the drug to flow out. At the same time, it can increase the bone mass in the later stage. Effect

Method used

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  • Method for producing 3D printed artificial bone
  • Method for producing 3D printed artificial bone
  • Method for producing 3D printed artificial bone

Examples

Experimental program
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Effect test

Embodiment 1

[0038] figure 1 This is a schematic flow chart of a manufacturing method of 3D printed artificial bone provided by an embodiment of this application. Such as figure 1 As shown, the method includes:

[0039] Step 101: Obtain 3D graphics through 3D CT;

[0040] Specifically, by performing a three-dimensional CT on the affected area of ​​the patient, a 3D stereoscopic image of the affected area is obtained, and the above-mentioned 3D stereoscopic image can truly see the shape of the bones of the affected area. For example, a patient has a bone tumor. After the bone tumor is surgically removed, there will be a gap in the bone in the affected area. The gap is determined by the size and shape of the bone tumor. It can be said that the gap after the removal of the bone tumor is all It is not the same, so through three-dimensional CT, you can get the same shape and size as the patient's bone gap.

[0041] Step 102: Obtain a 3D model of the closed bone window through modeling technology acc...

Embodiment 2

[0063] In order to achieve the use of more moderately sensitive drugs and further enhance the sustained release effect, the embodiments of the present application also provide a manufacturing method of 3D printed artificial bone, such as figure 2 As shown, the method includes:

[0064] Step 210: After adding the second paste-like material to the biological 3D printer and printing on the basis of the inner layer, the method further includes:

[0065] Step 220: Obtain a third sensitive drug, wherein the third sensitive drug is used for drug sensitivity to the target object, and the sensitivity of the second sensitive drug is lower than that of the third sensitive drug ;

[0066] Step 230: Dissolve the third sensitive drug in the solvent and prepare a third suspension;

[0067] Step 240: adding 0.5%-30% by weight of the calcium-containing compound in the third suspension to prepare a third paste material;

[0068] Step 250: Add the third paste material to a bio-3D printer, and then print...

Embodiment 3

[0071] In order to further improve the slow-release effect, the embodiments of the present application also provide a manufacturing method of 3D printed artificial bone, such as image 3 As shown, the method includes:

[0072] Step 310: Obtain the required first action time of the first sensitive drug;

[0073] Step 320: Obtain the total amount of the first sensitive drug according to the first action time;

[0074] Step 330: Determine the weight of the first paste material added to the biological 3D printer according to the total amount of medicine.

[0075] For the embodiments of the present application, different target objects may require different sustained release times according to their disease conditions, individual physical conditions, etc. Therefore, it is necessary to first determine the required release time of the sensitive drug. Specifically, for the first A sensitive drug needs the first time of action. Further, for the second sensitive drug, the release time correspo...

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Abstract

An embodiment of the invention provides a method for producing a 3D printed artificial bone. The method comprises the following steps: obtaining a 3D graphic through 3D CT; obtaining a modeling technology according to the 3D graphic and obtaining a 3D model of a closed bone window; obtaining a first sensitive drug and a second sensitive drug; preparing a first paste material from the first sensitive drug; adding the first paste material to a biological 3D printer for printing to form an inner layer; preparing a second paste material from the second sensitive drug; adding the second paste material to the biological 3D printer for printing on the basis of inner layer to form the artificial bone. The technical problems that requirements of different types of orthopedic surgery cannot be met and drugs cannot remain at parts requiring the drugs to play a role due to absence of a bone window closing system in the prior art are solved, and the technical effects that the artificial bone is matched with a bone window structure by means of 3D printing, drug blockage is facilitated and bone mass can be increased in late stage are realized.

Description

Technical field [0001] The invention relates to the field of medical technology, in particular to a manufacturing method of 3D printed artificial bone. Background technique [0002] Osteomyelitis is an infection and destruction of bone, which is caused by aerobic or anaerobic bacteria, mycobacteria and fungi. In the treatment of osteomyelitis, it is often necessary to fill the site of penetrating bone injury with bone cement and other materials. [0003] However, in the process of implementing the technical solutions of the invention in the embodiments of the present application, the inventor of the present application found that the above technology has at least the following technical problems: [0004] In the prior art, in the clinical treatment of osteomyelitis, there are often methods of bone removal and bone opening. The current sustained-release drugs used in clinical practice have a single shape and simple structure. The requirements of different types of orthopedic surgery...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/50A61L27/20A61L27/04A61L27/18A61L27/12B33Y10/00
CPCA61L27/54A61L27/04A61L27/12A61L27/18A61L27/20A61L27/50A61L2430/02B33Y10/00C08L5/08C08L67/04
Inventor 李征宇曾庆丰
Owner 迈海新型材料科技(固安)有限公司
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