Phosphorylated derivative of schizophyllan, and preparation method and application thereof

A technology of schizophyllan and phosphorylation, which is applied in the field of schizophyllan phosphorylated derivatives and their preparation, can solve the problems of expensive derivatization reagents, difficulty in completely dissolving, and limited application, and achieve simple, cheap, and water-soluble derivatization methods. Good sex, good immediate effect

Active Publication Date: 2018-02-09
ZHUHAI EASYCARE TECH CO LTD
View PDF10 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the molecular weight of Schizophyllan is usually over one million, it is difficult to dissolve completely in water, which greatly limits its application in cosmetics
It has been reported in the literature that schizophyllan was physically and chemically modified by methods such as sonication, carboxymethylation, and sulfation. However, the derivatization reagents are expensive, the yield is low,

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Phosphorylated derivative of schizophyllan, and preparation method and application thereof
  • Phosphorylated derivative of schizophyllan, and preparation method and application thereof
  • Phosphorylated derivative of schizophyllan, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 Schizophyllan phosphate A

[0029] Dissolve 1 g of Schizophyllan in 20 mL of dimethyl sulfoxide, slowly add 2.5 g of phosphorus pentoxide at a stirring speed of 100 rpm, and keep stirring for 1 h at a temperature of 100 ° C, then cool to room temperature, and Pour the reaction solution into ice water, adjust to neutral with sodium hydroxide solution, add 3 times the amount of ethanol to precipitate, centrifuge, filter, redissolve the precipitate in hot water, dialyze for 1 day, concentrate and freeze-dry to obtain the split fold Polysaccharide Phosphate A.

Embodiment 2

[0030] Preparation of Example 2 Schizophyllan Phosphate B

[0031] Dissolve 1g of Schizophyllan in 100mL of deionized water, slowly add 1g of sodium tripolyphosphate and 1g of sodium trimetaphosphate at a stirring speed of 300rpm, keep stirring for 5 hours at 60°C, and cool to At room temperature, add 3 times the amount of ethanol to the reaction solution to precipitate, centrifuge, filter, redissolve the precipitate in hot water, dialyze for 2 days, concentrate and freeze-dry to obtain Schizophyllan Phosphate B.

Embodiment 3

[0032] Example 3 Preparation of Schizophyllan Phosphate C

[0033] Dissolve 1g of Schizophyllan in 100mL of deionized water, slowly add 1.5g of sodium tripolyphosphate at a stirring speed of 150rpm, and keep stirring for 5 hours at a temperature of 60°C, cool to room temperature, and add 3 Precipitate with twice the amount of ethanol, centrifuge, filter, redissolve the precipitate in hot water, dialyze for 1 day, concentrate and freeze-dry to obtain Schizophyllan Phosphate B.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a phosphorylated derivative of schizophyllan. The phosphorylated derivative of schizophyllan is prepared from, by mass, 1 to 10% of schizophyllan ad 1.5 to 20% of a phosphorylation reagent, with the balance being a solvent. The invention also discloses a preparation method for the phosphorylated derivative of schizophyllan. The preparation method comprises the following steps: (1) adding schizophyllan and the phosphorylation reagent into the solvent and carrying out mixing and a stirring reaction; and (2) subjecting a reaction solution obtained after the reaction in thestep (1) to separation and purification so as to obtain the phosphorylated derivative of schizophyllan. The phosphorylated derivative of schizophyllan has the advantages of good instant and long-lasting effect when used as an antioxidation active component, a humectant and an anti-aging active component for preparation of external agents for skin.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a phosphorylated schizophyllan derivative, a preparation method and application thereof. Background technique [0002] With the improvement of living standards, people pay more and more attention to skin care (especially the care of facial skin). Skin care starts with replenishing skin moisture, because skin dehydration will not only reduce the metabolism and cell vitality of skin cells, resulting in fine lines, wrinkles, dullness, color spots and other problems on the skin, but also keep the skin in a sub-healthy state , leading to poor skin tolerance, easy to be stimulated by the outside world, causing allergies, red blood and other problems; the lack of water in the skin can also easily cause the imbalance of water and oil in the skin, forming a skin texture that is oily on the outside and dry on the inside, prone to acne, which is harmful to people's skin. Life...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C08B37/02A61K31/715A61K8/73A61Q19/00A61Q19/08A61P17/00
CPCA61K8/73A61K31/715A61Q19/00A61Q19/08C08B37/0024
Inventor 方兆华刘建欣冯小玲孙永周立武王德友
Owner ZHUHAI EASYCARE TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap